Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, was selected by the Awards Committee as the 2008 Society of Toxicologic Pathology Achievement Award recipient. Dr. Maronpot has significantly influenced the field of toxicologic pathology in many different ways, including as a leader, manager, educator, and author. He is internationally recognized and highly respected for his scientific contributions to toxicologic pathology and the advancement of the Society of Toxicologic Pathology (STP). Dr. Maronpot served as president of STP in 2001 and as editor-in-chief of its journal, Toxicologic Pathology, from 2001 to 2004.
Dr. Maronpot received his doctorate of veterinary medicine in 1965 from Michigan State University, an MS in nutritional pathology from Michigan State University in 1966, and an MPH from Harvard University in 1972. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology and has worked more than forty years in experimental pathology, with an emphasis on animal models of carcinogenesis. He serves on several journal editorial boards.
In addition to more than 250 peer-reviewed publications, he has edited a comprehensive text titled Pathology of the Mouse (1999), coedited a book titled Pathology of Genetically Engineered Mice (2000), and has several years of experience in the application of imaging technologies, especially magnetic resonance imaging (MRI), to toxicologic pathology. In 2007, he retired from the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP), where he was chief of the Laboratory of Experimental Pathology.
As a leader and manager, he started at the NIEHS as part of a very small, fledgling program of experimental pathology in 1981. During his appointment, his vision of increasing the impact of the pathologist in toxicology through a wider use of scientific tools was so successful that, by the end of his tenure, the program had expanded to fifty people, all dedicated to the elucidation of scientific issues in pathology. The pathologists on the current staff at NIEHS joined the program during his tenure and constitute a remarkable group of scientists.
As an educator, Dr. Maronpot also created the training program at NIEHS, where many toxicologic pathologists have been trained through the years. The program maintains two to three trainees, therefore creating a scholarly learning environment. He was the originator of the NTP Symposium held in conjunction with the STP Symposium that has always been well received and considered an important component of the meeting. Dr. Maronpot also has adjunct faculty appointments at Duke University, North Carolina State University, and the University of North Carolina.
In addition to his leadership role as editor of the Pathology of the Mouse, which is a seminal publication to all toxicologic pathologists, he was instrumental in organizing some of the first panels of pathologists to achieve better standardization of our terminology. Specifically impactful was his leadership in the definition of liver proliferative lesions as well as his role in the nomenclature of lesions of the forestomach. These early efforts set the tone for the achievement of consensus in the field and have been critical to the later achievement of clarity in our communication of risk assessment. Dr. Maronpot also contributed significantly to the use of in vivo imaging, particularly MRI and its use in the study of the development, progression, and regression of proliferative changes in rodents.
Dr. Maronpot continues to advance the profession by working as a consultant and striving to address some of the issues of consistency between pathologists. He is frequently sought out to provide expert advice on numerous national and international committees, working groups, and task forces. He serves as an example to the present and future membership for his scientific achievements and selfless dedication to the profession.
Robert R. Maronpot
Consultant in Toxicology and
Pathology
Contact
Information
Maronpot Consulting, LLC
Email:
Maronpot@me.com
Education
B.S., 1963 (Veterinary Science), Michigan State University
D.V.M., 1965 (Veterinary Medicine), Michigan State University
M.S., 1966 (Nutritional Pathology), Michigan State University
M.P.H., 1972 (Public Health), Harvard University
Specialty Boards & Honors
Diplomate, American College of Veterinary Pathologists,
1973
Diplomate, American Board of Toxicology, 1980
Distinguished Postdoctoral
Veterinary Alumnus Award from
Michigan State University College of Veterinary Medicine - 2000
President, Society of Toxicologic
Pathology - 2001-2002
Editor-in-Chief, Toxicologic Pathology – 2001-2004
Board of Directors, American Board of Toxicology – 1989-1993
Society of Toxicologic Pathology Achievement
Award - 2008
Fellow, International Academy of Toxicologic Pathology – 2009
Vice President,
International
Academy of Toxicologic
Pathology – 2010
President, International
Academy of Toxicologic
Pathology – 2011-Dec 2012
Secretary General, International Federation of Societies
of Toxicologic
Pathology – June 2014 - present
Recent Positions
Guest Researcher, Laboratory of Experimental
Pathology:
2007-2008
National Institute of Environmental Health Sciences, NIH
Chief, Laboratory of Experimental
Pathology:
1992
- 2007
National Institute of Environmental
Health Sciences, NIH, National Toxicology Program
Professional Organizations
American College of Veterinary
Pathologists
Society of Toxicologic
Pathologists
Society of Toxicology
British Society of Toxicologic
Pathology
European Society of Toxicologic Pathology
Lectures Since Retirement from NIEHS/National Toxicology Program
2007 Lectures
Society of Toxicology Annual Meeting Charlotte, NC – March 2007
Lectured at a Continuing Education Course Rodent Imaging Overview for the Toxicologist “Magnetic Resonance Imaging”
7th Biennial Industrial Toxicology & Pathology Short Course
University of Illinois – July 2007
“Carcinogenicity Assessment” and
“Application of Multimodality Imaging in Toxicologic Pathology”
American Association for Laboratory Animal Science Annual Meeting
Charlotte, NC – October 2007
The Wallace P. Rowe Lecture
“The Cancer Bioassay: Challenges for the Future”
and
Seminar on Current Imaging Modalities for Rodent Xenograft Models
“MRI Imaging Systems”
National Academy of Science Workshop on Mouse Liver Tumors
Washington, DC – November 2007
“Mouse Models for Carcinogenicity”
American College of Veterinary Pathologists
Savannah, Georgia – November 2007
Lectured at a Continuing Education Course Rodent Imaging Overview for the Pathologist “Magnetic Resonance Imaging”
2008 - 2011 Lectures
ILSI Annual Meeting
Rio Grande, Puerto Rico – January 2008
Organized symposium on “Applications of Small Animal Imaging in Toxicology Research and Testing”
Lectured on “Application of Magnetic Resonance Imaging in Toxicology and Toxicologic
Pathology”
NIEHS February 2008 Lecture on “Comparative Medicine Branch Pathology/Case Presentations”
Aperio Research Triangle Park Digital Pathology Seminar May 13, 2008
Lecture on “Digital Pathology for Peer Review and Phenotyping”
NTP Satellite Symposium, STP Annual meeting. Conundrums in Toxicologic Pathology
June 21, 2008, San Francisco
2nd East Mediterranean ICLAS Regional Meeting
“Overview of Imaging Modalities and Control of Small Animal Physiology During Live
Imaging”
and “Application of MRI in Toxicology and Toxicologic Pathology”
Jerusalem, Israel, December 3-4, 2008.
TEVA Pharmaceutical Company, Israel “The Cancer Bioassay: Past, Present, Future” December 8, 2008
Eighth Biennial Short Course: Toxicology & Pathology Drug Discovery and Development.
University of Illinois, Champaign/Urbana, Illinois
“The Cancer Bioassay: Past, Present, and Future” - July 21, 2009
Contemporary Concepts in Target Organ Toxicologic Pathology: Hepatobiliary and
Cardiovascular Systems
“Background Lesions and Nomenclature”
University of Illinois, Champaign/Urbana, Illinois
“The Cancer Bioassay: Past, Present, and Future” - July 22, 2009
“Xenobiotic-induced Toxicologic Pathology of the Liver.”
The BSTP Gopinath Lecture.
7th European Congress of Toxicologic Pathology, European Society of Toxicologic Pathology.
The Hague September 15-18, 2009
“Xenobiotic-induced Rodent Tumors of Questionable Relevance to Human Cancer Risk”
7th European Congress of Toxicologic Pathology, European Society of Toxicologic Pathology.
The Hague September 15-18, 2009
“Histopathology of Non-neoplastic Liver Lesions”
Osaka Perfecture University, Osaka, Japan January 24, 2011.
“Rodent Lesions That Are Not Significant for Human Risk”
Sumitomo Chemical Company
(January 25, 2011), DaiichiSankyo (January 31, 2011) and IET (February 1, 2011).
Japan
“Adverse Versus Adaptive Hepatic Enzyme Induction (Hypertrophy)”
JSTP Annual
Meeting, Osaka, Japan
January 27, 2011.
“Overview of Xenobiotic-Induced Hepatocellular Hypertrophy”
3rd International European Society of Toxicologic Pathology Workshop, Ivrea, Italy. June 1, 2011.
2012 Lectures
“Pathology of the Adrenal
Gland” Daiichi-Sankyo, Tokyo, Japan January 31, 2012
“Rodent Pulmonary
Lesions” JSTP Annual Meeting, Tokyo,
Japan February 1, 2012
“Current and Past Rat Strains
Used by the National Toxicology Program”
Harlan Evening Seminar, Tokyo, Japan February 3, 2012
“Image Acquisition and
Ethics” IATP Lecture at STP Annual
Meeting, Boston, MA , June 27, 2012
“Pathology of the Mouse:
Past, Present and Future” ACVP Annual Meeting, Seattle, Oregon, December 4,
2012
“Mice in Toxicity Studies: Inbred vs. Outbred Strains and Challenges of Background
Findings. European Society of Toxicologic Pathology, Uppsala, Sweden, Sept. 10,
2011
2013
Lectures
“The Role of the Toxicologic Pathologist in the
Post-Genomic Era”, 29th Annual Meeting of the Japanese Society of
Toxicologic Pathology, Tsukba, Tokyo, Japan. January 31, 2013.
Responsible Authorship and Publication Practices,
AALAS Annual Meeting, Baltimore, MD, 28 October 2013
2014
Lectures
Practical Applications of MRI Histology in
Toxicologic Pathology
30th Annual Meeting of the Japanese Society
of Toxicologic Pathology, Tokushima, Japan, January 29, 2014
Neoplastic and Non-neoplastic Rodent Thyroid
Lesions and Their Relevance
RTP Rodent Pathology Course, Research Triangle
Park, NC, September 22, 2014
Identifying Adverse Organ Responses: The Liver as
Paradigm
Annual Meeting of the American College of Toxicology, Orlando,
Florida, November 11, 2014
2015 Lectures
Responsible Authorship & Publication
Practices
31st Annual Meeting of the Japanese Society of
Toxicologic Pathology, Tokyo, Japan, January 28, 2015
INHAND Master Class: Rodent Liver Lesions –
Neoplastic, BSTP CE Symposium 3, Cambridge, UK; 25-27 March, 2015
Liver Lesions and Significance to Man, , BSTP
CE Symposium 3, Cambridge, UK; 25-27 March, 2015
Liver Carcinogenesis and the Use of Rat and
Mouse Models, , BSTP CE Symposium 3, Cambridge, UK; 25-27 March, 2015
Publications
Maronpot RR and Whitehair CK, 1967. Experimental
Sprue-like Small Intestinal Lesions in Pigs. Can. J. Comp. Med. 31:309-316.
Maronpot RR, Stedman
MA, and Bucci TJ, 1968. Focal Degenerative Myopathy
in Turkeys. Avian
Dis. 12:96-103.
Stedham MA, Bucci TJ, and Maronpot RR, 1968. Sexual and Asexual Phases of Aspergillus
Nidulans in an Egret. Myopath. et Mycologia
Appli. 36:289-292.
Maronpot RR and Michael
SA, 1968. Toxoplasmosis in Sheep. A Review.
J. Egypt. Vet. Med. Assoc. 28:155-163.
Maronpot RR and Guindy E, 1970. Preliminary Study of Babesia Gibsoni
Patton in Wild Carnivores and Domesticated
Dogs in Egypt. Amer. J. Vet. Res. 31:797-799.
Maronpot RR and Ezzat E, 1970. Hematologic Values for Cairo Dogs. Proc. 9th Arab Vet. Congress,
Cairo, Egypt. pp. 124-134.
Maronpot RR and Abd El Hei Refaii, 1970. The Histopathology
of Klosiella Equi in Egyptian
Equines. Proc. 9th Arab Vet. Congress, Cairo, Egypt. pp. 226-235.
Botros BA M, Awad AY, Kozman
AR, Hildebrandt PK, and Maronpot
RR, 1970. Hematologic,
Blood
Electrolyte and Blood Biochemical Values of Egyptian
Domesticated
Animals.
J. Egypt. Vet. Med Assoc. 30: 53-61
Michael SA, Maronpot RR, and Botros BAM, 1970. Blood Parasites in Egyptian
Animals.
Proc. 9th
Arab Vet. Congress, Cairo, Egypt. pp. 236-254.
Waslien CI, Maronpot RR, and Kozman AR, 1970. Nutritional Studies
in the Sand Rat
(Psammomys obesus). Pahlavi Medical J. 1:228-233.
Maronpot RR, Barsoum IS, and Ezzat E, 1971. Canine
Leptospirosis in Cairo. United Arab
Republic. The J. of Infectious
Diseases. 123:548-550.
Wilson BJ and Maronpot
RR, 1971. Causative
Fungus Agent of Leukoencephalomalacia in Equine
Animals. Vet. Rec. 88:484-486.
Attia MAM, Williams RE, Maronpot
RR, El Mour AF, and Moussa
MI, 1971. Pathogenicity of Wad
Medani Virus to Selected Animals. J. Egypt. Pub. Hlth. Assoc. 46:326-336.
Maronpot RR, 1972. Erythrocyte
Glucose-6-phosphate Dehydrogenase and Glutathione
Deficiency in Sheep. Can. J. Comp. Med. 36:55-60.
Maronpot RR and Barsoum IS, 1972. Leptospiral
Microscopic
Agglutinating Antibodies
in Sera of
Man and Domestic
Animals in Egypt. Amer. J. Trop. Med. Hyg. 21:467-472.
Maronpot RR and Botros BAM, 1972. Toxoplasma Serologic Survey in Man and Domestic
Animals in Egypt. J. Egypt. Pub. Hlth. Assoc. 47:58-67.
Wilson BJ, Maronpot
RR, and Hildebrandt PK, 1973. Equine Leukoencephalomalacia. J. Amer. Vet. Med. Assoc. 163:1293-1295.
Maronpot RR, Michael
SA, and Botros BAM, 1974. Blood Parasites
in Egyptian Domestic
Animals. J. Egypt. Vet. Med. Assoc. 34:301-308.
Botros BAM and Maronpot RR, 1974. Complement-fixing and Indirect Fluorescent
Antibodies in
Sera of Dogs Experimentally
Infected with Babesia
Gibsoni.
J. Egypt. Vet. Med. Assoc. 34:309-321.
Hoffman D, Raineri R, Hecht S, Maronpot
RR, and Wynder EL, 1975. A Study of Tobacco
Carcinogenesis. XIV. Effects of N'-nitrosonornicotine and N'-nitrosoanabasine in Rats. JNCI
55:977-981.
Hecht SS, Thorne
RL, Maronpot RR, and Hoffman D, 1975. A Study of Tobacco
Carcinogenesis. XIII. Tumor Promoting
Subfractions
of the Weakly Acidic Fraction. JNCI 55:1329-1336.
Hecht SS, Loy M, Maronpot RR, and Hoffmann D, 1976. A Study of Chemical Carcinogenesis: Comparative
Carcinogenicity of 5-Methylchrysene, Benzo (a) Pyrene
and Modified
Chrysenes. Cancer Ltrs. 1:147-153.
Narisawa T, Wong CQ, Maronpot
RR, and Weisburger JH, 1976. Large Bowel Carcinogenesis
in Mice and Rats by Several Intrarectal
doses of Methylnitrosourea and Negative Effect of Nitrite plus Methylurea.
Cancer Res. 36:505-510.
Maronpot RR and Chavannes
JM, 1977. Dacryoadenitis, Conjunctivitis, and Facial Dermatitis of the
Mouse. Lab. Anim. Sci. 27:277.
Anderson LM, Budinger JM, Maronpot RR, and Good RA, 1978. Transplacental
Lung
Tumorigenesis in the Athymic
Mouse. Cancer Res. 38:137-141.
McGee MA and Maronpot RR, 1979. Harderian Gland Dacryoadenitis in Rats Resulting from Orbital
Bleeding. Lab. Anim. Sci. 29:639-641.
Burton DS, Maronpot
RR, and Howard
FL, 1979. Frequency of Hydronephrosis
in Wistar Rats. Lab. Anim. Sci. 29:642-644.
Maronpot RR and Peterson
LG, 1981. Spontaneous Proteus
Nephritis
Among
Male C3H/HeJ Mice.
Lab. Anim. Sci. 31:697-700.
Snellings WM, Maronpot RR, Zelenak
JP, and Laffoon
CP, 1982. Teratology
Study in Fischer
344
Rats Exposed
to Ethylene
Oxide by Inhalation. Tox. & Appl. Pharmacol. 64:476-481.
Maronpot RR and Boorman GA, 1982. Interpretation of Rodent Hepatocellular
Proliferative
Alterations and Hepatocellular
Tumors
in Chemical
Safety Assessment. Tox. Path. 10:71-80.
Maronpot RR, Witschi HP, Smith LH, and McCoy
JL, 1983. Recent
Experience
with the Strain A Mouse Pulmonary Tumor Bioassay Model. In Short-Term Bioassays in
the Analysis of
Complex Environmental
Mixtures III. Environ. Sci. Res. 27:341-350.
Dodd DE, Snellings
WM, Maronpot
RR, and Ballantyne
B, 1983. Ethylene Glycol Monobutyl
Ether: Acute, 9-day, and 90-day Vapor Inhalation
Studies in Fischer 344 Rats. Tox. & Appl. Pharmacol.
68:405-414.
Maronpot RR, Zelenak
JP, Weaver
EV, and Smith NJ, 1983. Teratogenicity Study of Ethylene
Glycol in Rats. Drug & Chem. Toxicol.
6:579-594.
Yang RSH, Garman
RH, Maronpot RR, McKelvey JA, Weil CS, and Woodside MD, 1983. Acute and Subchronic Toxicity of Ethylenediamine in Laboratory Animals. Fund. & Appl. Tox. 3:512-520.
Snellings WM, Weil CS, and Maronpot RR, 1984. A Two-Year
Inhalation
Study of the Carcinogenic
Potential of Ethylene
Oxide in Fischer
344 Rats. Tox. & Appl. Pharmacol. 75:105-117.
Kluwe WM, Maronpot RR, Greenwell
A, Harrington F, 1984. Interactions
Between Bromobenzene Dose, Glutathione
Concentrations, and Organ
Toxicities
in Single
and Multiple
Treatment
Studies. Fund. & Appl. Tox. 4:1019-1028.
Snellings WM, Weil CS, and Maronpot RR, 1984. A Subchronic Inhalation Study on the Toxicologic
Potential of Ethylene Oxide in B6C3F1 Mice. Tox. & Appl. Pharmacol.
76:510-518.
Agarwal DK, Maronpot
RR, Lamb IV JC, and Kluwe WM, 1985. Adverse Effects of Butyl Benzyl
Phthalate on the Reproductive and Hematopoietic System of Male Rats. Toxicology
35:189-206.
Choy WN, MacGregor
JT, Shelby MD, and Maronpot RR, 1985. Induction of Micronuclei by Benzene in B6C3F1
Mice: Retrospective
Analysis of Peripheral Blood Smears from the NTP Carcinogenesis Bioassay.
Mutation
Res. 143:55-59.
Ghanayem BI, Maronpot
RR, and Matthews
HB, 1985. Ethyl Acrylate-Induced Gastric Toxicity.
I. Effect of Single and Repetitive Dosing. Tox. & Appl. Pharmacol. 80:323-335.
Ghanayem BI, Maronpot
RR, and Matthews
HB, 1985. Ethyl Acrylate-Induced Gastric Toxicity.
II. Structure - Toxicity Relationships
and Mechanism. Tox. & Appl. Pharmacol.
80:336-
344.
Garman RH, Snellings WM, and Maronpot RR, 1985. Brain Tumors in F344 Rats Associated
with
Chronic Inhalation Exposure to Ethylene Oxide . NeuroToxicology 6:117-138.
Lamb JC, Maronpot
RR, Gulati DK, Russell VS, Hommel
L, and Sabharwal PS, 1985. Reproductive and Developmental
Toxicity of Ethylene Glycol in the Mouse.
Tox. & Appl. Pharmacol. 81:100-112.
Dieter MP, Maronpot RR, and French JF, 1985. Comparison of the Morphology
and Enzyme Activity of Mononuclear
Cells From Fischer 344 Rats with Either Spontaneous or Transplanted Leukemia. Cancer Res. 45:4301-4307.
Cline JM and Maronpot RR, 1985. Variations in the Histologic
Distribution of Rat Bone Marrow
Cells with Respect to Age and Anatomic
Site. Tox. Path. 13:349-355.
DePass LR, Maronpot RR, and Weil WS, 1985. Dermal Oncogenicity
Bioassays of Monofunctional and Multifunctional
Acrylates
and Acrylate-based
Oligomers. J. Tox. and Environ. Hlth. 16:55-60.
DePass LR, Garman
RH, Woodside MD, Boyce JT, Giddens WE, Maronpot
RR, and Weil CS,
1986. Chronic
Toxicity and Oncogenicity
Studies of Ethylene
Glycol in Rats and Mice. Fund. &. Appl. Tox. 7:547-565.
DePass LR, Woodside
MD, Maronpot
RR, and Weil CS, 1986. Three-Generation Reproduction and
Dominant Lethal Mutagenesis
Studies of Ethylene Glycol in the Rat. Fund. & Appl. Tox. 7:566- 572.
Garman RH, Snellings WM, and Maronpot RR, 1986. Frequency, Size and Location
of Brain
Tumours in F-344 Rats Chronically Exposed
to Ethylene
Oxide. Fd. Chem. Tox. 24(2):145-153.
Reynolds SH, Stowers SJ, Maronpot RR, Anderson
MW, and Aaronson
SA, 1986. Detection and Identification of Activated
Oncogenes
in Spontaneously Occurring
Benign and Malignant Hepatocellular Tumors of the B6C3F1
Mouse.
Proc. Nat'l. Acad. Sci. 83:33-37.
Klinger W, Devereux T, Maronpot
RR, and Fouts J, 1986. Functional Hepatocellular
Heterogeneity
Determined by the Hepatotoxins
Allyl Alcohol
and Bromobenzene
in Immature
and Adult F344
Rats. Tox. & Appl. Pharmacol. 83:108-114.
Maronpot RR, Montgomery
CA, Boorman
GA, and McConnell EE, 1986. National Toxicology
Program Nomenclature
for Hepatoproliferative Lesions of Rats. Tox. Path. 14:163-273.
Maronpot RR, Shimkin MB, Smith LH, Witschi HP, and Cline JM, 1986. Strain A Mouse Pulmonary Tumor Test Results for Chemicals Previously Tested in the National
Cancer Institute Carcinogenicity Tests. JNCI. 76:1101-1112.
Maronpot RR, Miller RA, Clarke WJ, Westerberg
RB, Decker JR, and Moss OR, 1986. Toxicity
of
Formaldehyde Vapor in B6C3F1 Mice Exposed
For 13 Weeks. Toxicology 41:253-266.
Ghanayem BI, Maronpot RR, and Matthews HB, 1986. Association of Chemically
Induced
Forestomach Cell Proliferation and Carcinogenesis. Cancer Ltrs. 32:271-278.
Ghanayem BI, Maronpot
RR, and Matthews
HB, 1986. Ethyl Acrylate-Induced Gastric Toxicity.
III. Development and Recovery of Lesions.
Tox. & Appl. Pharmacol. 83:576-583.
Boorman GA, Hong HL, Jameson
CW, Yoshitomi K, and Maronpot
RR, 1986. Regression of Methyl
Bromide Induced Forestomach
Lesions
in the Rat. Tox. & Appl. Pharmacol. 86:131-139
Yoshitomi K, Maronpot
RR, Solleveld
HA, and Boorman
GA, 1986. Forestomach Ulcers in Crj:B6C3 (C57BL/6NCrj x C3H/HeNCrj)
F1 Mice. Lab. Anim. Sci. 36(5):501-503.
Wilson WE, Hudson
PM, Kanamatsu T, Walsh TJ, Tilson HA, Hong JS, Maronpot
RR, and Thompson
M, 1986. Trimethyltin-
Induced
Alterations in Brain Amino Acids, Amines and Amine Metabolites:
Relationship
to Hyperammonemia. NeuroToxicology 7(3):63-74.
Dieter MP, Maronpot
RR, and French JE, 1987. Biochemical Markers
for Fischer Rat Leukemia
in a
Cell Transplant
Model. Cancer Detection
and Prevention 10:425-433.
Ghanayem BI, Matthews
HB, and Maronpot RR, 1987. Calcium Channel
Blockers
Protect Against
Ethanol - and Indomethacin-
Induced
Gastric Lesions
in Rats. Gastroenterology 92:106-111.
Miller BE, Chapin RE, Pinkerton
KE, Gilmore LB, Maronpot
RR, and Hook GER, 1987. Quantitation of Silica-Induced Type II Cell Hyperplasia by Using Alkaline Phosphatase Histochemistry
in Glycol Methacrylate Embedded Lung. Exp. Lung Res. 12:135-148.
Maronpot RR, Haseman
JK, Boorman GA, Eustis SE, Rao GN, and Huff JE, 1987. Liver Lesions in
B6C3F1 Mice: The National
Toxicology Program, Experience and Position. Arch. Toxicol.
Suppl.
10:10-26.
Mitsumori K, Maronpot
RR, and Boorman
GA, 1987. Spontaneous Tumors of the Meninges
in Rats. Vet. Path. 24:50-58.
Melnick RL, Jameson
CW, Goehl TJ, Maronpot RR, Collins BJ, Greenwell
A, Harrington FW, Wilson RE, Tomaszewski KE, and Agarwal
DK, 1987. Application of Microencapsulation for Toxicology
Studies.
II. Toxicity of Microencapsulated Trichloroethylene in Fischer
344 Rats. Fund.
& App. Tox. 8:432-442.
Maronpot RR, 1987. Ovarian Toxicity and Carcinogenicity
in Eight Recent National Toxicology
Program Studies. EHP 73:125-130.
Campen DB, Sloop TC, Maronpot RR, and Lucier GW, 1987. Continued Development
of Hepatic
g- Glutamyltranspeptidase - Positive Foci Upon Withdrawal
of 17-a-Ethynylestradiol in Diethylnitrosamine-initiated Rats. Cancer Res. 47:2328-2333.
Stowers SJ, Glover PL, Reynolds
SH, Boone LR, Maronpot RR, and Anderson
MW, 1987. Activation of the K-ras Protooncogene
in Lung Tumors
from Rats and Mice Chronically
Exposed to Tetranitromethane. Cancer Res. 47:3212-3219.
Hsieh LL, Hsiao WL, Peraino
C, Maronpot RR, and Weinstein IB, 1987. Expression
of Retroviral
Sequences and Oncogenes
in Rat Liver Tumors Induced by Diethylnitrosamine. Cancer Res.
47:3421-3424.
Belinsky SA, Walker VE, Maronpot RR, Swenberg JA, and Anderson MW, 1987. Molecular Dosimetry of DNA Adduct Formation and Cell Toxicity in Rat Nasal Mucosa
Following Exposure to the Tobacco
Specific
Nitrosamine (N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their Relationship
to Induction of Neoplasia. Cancer Res. 47:6058-6065.
Mitsumori K, Dittrich KL, Stefanski S, Talley FA, and Maronpot
RR, 1987. Immunohistochemical
and Electron
Microscopic
Study of Meningeal Granular
Cell Tumors in Rats. Vet. Path. 24:356-359.
Ghanayem BI, Blair P, Thompson
MB, Maronpot
RR, and Matthews
HB, 1987. Effect of Age on the
Toxicity and Metabolism
of Ethylene
Glycol Monobutyl Ether (2-Butoxyethanol) in Rats. Tox. & Appl. Pharmacol. 91:222-234.
Reynolds SH, Stowers SJ, Patterson RM, Maronpot RR, Aaronson
SA, and Anderson MW, 1987. Activated
Oncogenes in B6C3F1
Mouse Liver Tumors:
Implications
For Risk Assessment.
Science 237:1309-1316.
Stowers SJ, Maronpot
RR, Reynolds SH, and Anderson
MW, 1987. The Role of Oncogenes
in
Chemical Carcinogenesis.
EHP 75:81-86.
Pitot HC, Goldsworthy
T, Moran
S, Kennan W, Glauert H, Maronpot
RR, and Campbell
HA, 1987. A Method
to Quantitate
the Relative
Initiating
and Promoting Potencies of Hepatocarcinogenic Agents in Their Dose-Response Relationships
to Altered Hepatic Foci. Carcinogenesis
8:1491-1499.
Goering PL, Maronpot
RR, and Fowler BA, 1988. Effect of Intratracheal
Gallium Arsenide Administration
on d-Aminolevulinic Acid Dehydratase
in Rats: Relationship
to Urinary
Excretion
of Aminolevulinic
Acid. Toxicol. Appl. Pharmacol. 92:179-193.
Reynolds SH, Stowers,
SJ, Patterson
RM, Maronpot
RR, and Anderson MW, 1988. Oncogene Activation
in Spontaneous
and Chemically Induced Rodent Tumors:
Implications
for Risk Analysis. EHP 78:175-177.
Hong HL, Huff JE, Luster MI, Maronpot RR, Dieter MP, Hayes HT, and Boorman
GA, 1988. The Effects of Allyl Isovalerate on the Hematopoietic
and Immunologic
Systems in Rodents.
Fund. & Appl. Tox. 10:655-663.
Belinsky SA, Dolan ME, White CM, Maronpot
RR, Pegg AE, and Anderson
MW, 1988. Cell Specific Differences
in O6-Methylguanine- DNA Methyltransferase Activity and Removal
of 06- Methylguanine in Rat Pulmonary
Cells. Carcinogenesis 9:2053-2058.
Peraino C, Carnes BA, Stevens FJ, Staffeldt EF, Russell JR, Prapuolenis
A, Blomquist JA, Vesselinovitch
SD, and Maronpot RR, 1988. Comparative Developmental
and Phenotypic Properties
of Altered Hepatocyte
Foci and Hepatic Tumors in Rats. Cancer Res. 48:4171-4178
Germolec DR, Maronpot RR, Ackermann MF, Vore SJ, Dittrich K, Rosenthal GJ, and Luster MI,
1988. Lack of a Relationship Between
Immune Function
and Chemically Induced
Hepatocarcinogenesis in B6C3F1
Mice. Cancer Immunology Immunotherapy 27:121-127.
Maronpot RR, Ulland B, and Mennear
J, 1988. Transplantation
Characteristics, Morphologic
Features, and Interpretation
of Preputial Gland Neoplasia
in the Fischer-344
Rat. EHP 77:33-36
Dixon D, Johnson GA, Cofer GP, Hedlund
L.W, and Maronpot RR, 1988. Magnetic
Resonance
Imaging (MRI): A New Tool in Experimental Toxicologic Pathology. Tox. Path. 16:386-391.
Graham MJ, Lucier GW, Linko P, Maronpot
RR, Goldstein JA, 1988. Increases
in Cytochrome P-
450 Mediated 17-b-Estradiol 2- Hydroxylase
Activity in Rat Liver Microsomes after both Acute Administration and Subchronic Administration of 2,3,7,8-Tetrachlorodibenzo- p-dioxin in a Two- stage Hepatocarcinogenesis Model. Carcinogenesis 9:1935- 1941.
Goldstein JA, Graham MJ, Sloop T, Maronpot RR, Goodrow
T, and Lucier GW, 1989. Effects of
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Estradiol
Metabolism,
Enzyme-altered Foci in a
Two stage Hepatocarcinogenesis Model in Rats. Chemosphere 18:695-700.
Pitot HC, Goodspeed D, Dunn T, Hendrich
S, Maronpot RR, and Moran S, 1989. Regulation
of the Expression of Some Genes for Enzymes of Glutathione
Metabolism
in Hepatotoxicity and Hepatocarcinogenesis. Tox. & Appl. Pharmacol. 97:23-34.
You M, Candrian
U, Maronpot RR, Stoner GD, and Anderson MW, 1989. Activation
of the Ki-ras Protooncogene in Spontaneously
Occurring
and Chemically Induced Lung Tumors of the Strain A Mouse.
Proc. Natl. Acad. Sci. 86:3070-3074.
Johnson GA, Thompson MB, Cofer GP, Campen D, and Maronpot
RR, 1989. Magnetic Resonance
Imaging of Hepatic
Neoplasms in the Rat. Vet. Path. 26:303-308.
Farmer THR, Johnson GA, Cofer GP, Maronpot
RR, Dixon D, and Hedlund
LW, 1989. Implanted
Coil MR Microscopy
of Renal Pathology.
Magnetic
Resonance in Medicine. 10:310-323.
Huff JE, Haseman
JK, Demarini
DM, Eustis S, Maronpot
RR, Peters AC, Persing
RL, Chrisp CE, and Jacobs AC, 1989. Multiple-Site
Carcinogenicity of Benzene
in Fischer-344
Rats and B6C3F1
Mice. EHP 82:125-163.
Belinsky SA, Devereux
TR, Maronpot RR, Stoner GD, and Anderson MW, 1989. Relationship between the Formation
of Promutagenic Adducts and the Activation of the K-ras Protooncogene
in Lung Tumors from A/J Mice Treated with Nitrosamines. Cancer Res. 49:5305-5311.
Ulland BM, Maronpot RR, Lemen JK, and Mennear JH, 1989. Transplantation
Studies of Preputial Gland and Epithelial
Skin Neoplasms Derived from Benzidine-based Dye Carcinogenicity Assays in Fischer
344 Male Rats. Tox. Path. 17:50-56.
Harada T, Maronpot RR, Morris RW, Stitzel KA, and Boorman
GA, 1989. Morphological
and Stereological
Characterization of Hepatic
Foci of Cellular
Alteration in Control Fischer 344 Rats. Tox. Path. 17:579-593.
Pitot, HC, Campbell, HA, Maronpot
R, Bawa N, Rizva TA, Xu Y, Sargent L, Dragan
Y, and Pyron M,
1989. Critical Parameters
in the Quantitation
of the Stages of Initiation, Promotion,
and Progression in One Model of Hepatocarcinogenesis in the Rat. Tox. Path. 17:594-612.
Johnson, GA and Maronpot
RR, 1989. Magnetic Resonance
Microscopy of Chemically-induced
Liver Foci. Tox. Path. 17:613-616.
Maronpot RR, Pitot HC, and Peraino
C, 1989. Use of Rat Liver Altered
Focus Models for Testing
Chemicals that have Completed
Two-year Carcinogenicity
Studies.
Tox. Path. 17:651-662.
Maronpot RR, Harada T, Murthy ASK, and Boorman
GA, 1989. Documenting
Foci of Hepatocellular Alteration in Two-year Carcinogenicity
Studies:
Current
Practices
of the National
Toxicology Program. Tox. Path. 17:675-684.
Harada T, Maronpot RR, Morris RW, and Boorman
GA, 1989. Observations on Altered Hepatocellular Foci in National Toxicology
Program Two-year Carcinogenicity
Studies in Rats. Tox. Path. 17:690-708.
Reynolds SH, Patterson
RM, Mennear
JH, Maronpot
RR, and Anderson MW, 1990. Ras Gene
Activation in Rat Tumors Induced by Benzidine
Congeners
and Derived
Dyes. Cancer Res. 50:266-
272.
Campen D, Maronpot
RR, and Lucier G, 1990. Dose-response
Relationships in Promotion
of Rat
Hepatocarcinogenesis by 17-a-ethinylestradiol. J. Tox. & Environ. Hlth. 29:257-268.
Harada T, Maronpot
RR, Morris RW, and Boorman GA, 1990. Effects of Mononuclear
Cell
Leukemia on Altered
Hepatocellular Foci in Fischer
344 Rats. Vet. Path. 27:110-116.
Xu YH, Campbell HA, Sattler GL, Hendrich
S, Maronpot R, Sato K, and Pitot HC, 1990. Quantitative
Stereological Analysis
of the Effects of Age and Sex on Multistage Hepatocarcinogenesis in the Rat by Use of 4 Cytochemical
Markers.
Cancer Res. 50:472-479.
Xu YH, Maronpot
RR, and Pitot HC, 1990. Quantitative
Stereologic
Study of the Effects of Varying the Time Between
Initiation
and Promotion on 4 Histochemical
Markers in Rat-liver During Hepatocarcinogenesis. Carcinogenesis 11:267-272.
Dieter MP, Jameson CW, Maronpot RR, Langenbach R, and Braun AG, 1990. The Chemotherapeutic Potential of Glycol Alkyl Ethers: Structure- activity Studies
of Nine Compounds in a Fischer
Rat Leukemia Transplant
Model. Cancer Chemo. &
Pharmacol.
26: 173-180.
Uraih LC and Maronpot
RR, 1990. Normal Histology of the Nasal Cavity and Application
of Special
Techniques. EHP 85: 187-208.
Maronpot RR, 1990. Pathology Working Group Review of Selected Upper Respiratory Tract
Lesions in Rats and Mice. EHP 85: 331-352.
Belinsky SA, Foley JF, White KM, Anderson
MW, and Maronpot
RR, 1990. Dose-response Relationship Between
O6-methylguanine Formation
in Clara Cells and Induction of Pulmonary Neoplasia
in the Rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 50: 3772-
3780.
Goodrow T, Reynolds
S, Maronpot R, and Anderson
M, 1990. Activation
of K-ras by Codon 13
Mutations in C57BL/6
x C3H F1 Mouse Tumors Induced by Exposure to 1,3-butadiene.
Cancer
Res. 50: 4818-4823.
Dittrich KL, Smith R, and Maronpot
RR, 1990. Stability of Gamma-glutamyltranspeptidase (GGT) in
Paraffin Embedded
Liver Tissue. The J. of Histotechnology 13:185-187.
Cunningham ML, Foley J, Maronpot
RR, and Matthews
HB, 1991. Correlation
of Hepatocellular
Proliferation with Hepatocarcinogenicity Induced
by the Mutagenic Noncarcinogen:Carcinogen pair
- 2,6- and 2,4-diaminotoluene. Tox. & Appl. Pharmacol.
107:562-567.
Lucier GW, Trischer A, Goldsworthy
T, Foley J, Clark G, Goldstein J, and Maronpot
RR, 1991. Ovarian
Hormones
Enhance 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin-mediated Increases in Cell Proliferation and Preneoplastic Foci in a Two-stage
Model for Rat Hepatocarcinogenesis. Cancer Res. 51:1391-1397.
Dragan YP, Rizvi T, Xu YH, Hully JR, Bawa N, Campbell
HA, Maronpot RR, and Pitot HC, 1991. An Initiation-Promotion Assay in Rat Liver as a Potential Complement
to the 2-year Carcinogenesis Bioassay. Fund. & Appl. Tox. 16:525-547.
Dixon D, Horton J, Haseman JK, Talley F, Greenwell A, Nettesheim P, Hook GE, and Maronpot RR, 1991. Histomorphology and
Ultrastructure of Spontaneous Pulmonary
Neoplasms in Strain A Mice. Exp. Lung Res. 17:131-155.
Foley JF, Anderson MW, Stoner GD, Gaul BW, Hardisty
JF, and Maronpot
RR, 1991. Proliferative lesions of the Mouse Lung: Progression Studies
in Strain A Mice. Exp. Lung Res. 17:157-168.
Belinsky SA, Devereux
TR, White CM, Foley JF, Maronpot RR, and Anderson
MW, 1991. Role of Clara Cells and Type II cells in the Development
of Pulmonary Tumors in Rats and Mice Following Exposure to a Tobacco-specific Nitrosamine. Exp. Lung Res. 17:263-278.
Maronpot RR, Palmiter
RD, Brinster
RL, and Sandgren EP, 1991. Pulmonary Carcinogenesis
in
Transgenic Mice. Exp. Lung Res. 17:305-320.
You M, Wang Y, Lineen A, Stoner GD, You L, Maronpot RR, and Anderson
MW, 1991. Activation of
Protooncogenes in Mouse Lung Tumors.
Exp. Lung Res. 17:389-400.
Maronpot RR, 1991. Correlation of Data from the Strain A Mouse Bioassay with Long-term
Bioassays. Exp. Lung Res. 17:425-431.
Ghanayem BI, Maronpot RR, and Matthews HB, 1991. Effects of Sulfhydryl Modulation on Ethyl
Acrylate-induced Forestomach
Toxicity.
Tox. Ltrs. 55:215-221.
Blair PC, Thompson
MB, Wilson RE, Esber HH, and Maronpot RR, 1991. Correlation of Changes
in
Serum Analytes and Hepatic Histopathology
in Rats Exposed
to Carbon Tetrachloride.
Tox. Ltrs.
55:149-159.
Hedlund LW, Maronpot
RR, Johnson
GA, Cofer GP, Mille GM, and Wheeler CT, 1991. Magnetic Resonance Microscopy
of Toxic Renal Injury Induced
by Bromoethylamine in Rats. Fund. & Appl. Tox. 16:787-797.
Candrian U, You M, Goodrow
T, Maronpot RR, Reynolds
SH, and Anderson MW, 1991. Activation of Protooncogenes in Spontaneously Occurring
non-Liver
Tumors
from C57BL/6
x C3H F1 Mice. Cancer Res. 51:1148-1153.
Greenwell A, Foley J.F, and Maronpot RR, 1991. An Enhancement Method for Immunohistochemical Staining of Proliferating
Cell Nuclear Antigen
in Archival
Rodent Tissues. Cancer Ltrs. 59:251-256.
Dixon D, Marshall
KLE, Greenwell A, Shimizu
T, Nettesheim
P, and Maronpot RR, 1991. Comparison of Automated
and Manual Staining
Techniques for the Binding
of Wheat Germ Agglutinin (WGA) in Modified
B5- and Formalin-fixed Pulmonary
Tissue. The J. of Histotechnology
14:149-153.
Maronpot RR, Giles HD, Dykes DJ, and Irwin RD, 1991. Furan-induced Hepatic
Cholangiocarcinomas in Fischer 344 Rats. Tox. Path. 19:561-570.
Brown HR, Monticello
TM, Maronpot
RR, Randall
HW, Hotchkiss
JR, and Morgan KT, 1991. Proliferative and Neoplastic
Lesions
in the Rodent Nasal Cavity. Tox. Path. 19:358-372.
Dixon D and Maronpot
RR, 1991. Histomorphologic Features of Spontaneous and Chemically- induced
Pulmonary Neoplasms
in B6C3F1 Mice and Fischer 344 Rats. Tox. Path. 19:540-556.
Foley JF, Dietrich DR, Swenberg JA, and Maronpot RR, 1991. Detection
and Evaluation
of Proliferating
Cell Nuclear Antigen
(PCNA)
in Rat Tissue by an Improved Immunohistochemical Procedure. The J. of Histotechnology 14:237-241.
Ghanayem BI, Matthews
HB, and Maronpot RR, 1991. Sustainability of Forestomach
Hyperplasia in Rats Treated with Ethyl Acrylate
for 13 Weeks
and Regression
After Cessation of Dosing. Tox. Path. 19:273-279.
Whitehead Jr. RE, Sugawara O, Maronpot
RR, Gladen BC, and Barrett JC, 1992. Detection
of Multiple
Tumor Suppressor Genes for Syrian Hamster
Fibrosarcomas by Somatic Cell Hybridization.
Somatic
Cell and Molecular Genetics 18:131-142.
Belinsky SA, Devereux
TR, Foley JF, Maronpot
RR, and Anderson MW, 1992. Role of the Alveolar type-II Cell in the Development
and Progression
of Pulmonary Tumors Induced
by 4- (methylnitrosamino)-1- (3-pyridyl)-1-butanone
in the A/J Mouse.
Cancer Res. 52:3164-3173.
Lindamood III C, Farnell DR, Giles HD, Prejean JD, Collins JJ, Takahashi K, and Maronpot
RR,
1992. Subchronic Toxicity Studies of t-butyl Alcohol
in Rats and Mice. Fund. & Appl. Tox. 19:91-
100.
You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds
S, and Anderson M, 1992. Parental Bias of Ki-ras Oncogenes Detected in Lung Tumors from Mouse Hybrids.
Proc. Natl. Acad. Sci, USA
89:5804-5808.
Dieter MP, Maronpot RR, Jameson
CW, and Ward SM, 1992. The Effects of Iodinated Glycerol, Trichlorfon,
and Acetaminophen on Tumor Progression in a Fischer
Rat Leukemia Transplant Model. Cancer Detection
and Prevention 16:173-183.
Lucier GW, Clark G, Tritscher
A, Foley J, and Maronpot R, 1992. Mechanisms of Dioxin Tumor
Promotion - Implications
for Risk Assessment. Chemosphere 25:177-180.
Xu YH, Dragan YP, Maronpot
RR, Goldsworthy
TL, and Pitot HC, 1992. Criteria,
Mechanisms,
and
Potency Evaluation for Tumor Promoters: Dioxin as a Model. Chemosphere
25:227-230.
Dragan YP, Xu YH, Goldsworthy TL, Campbell HA, Maronpot
RR, and Pitot HC, 1992. Characterization of the Promotion of Altered
Hepatic
Foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Female Rat. Carcinogenesis 13:1389-1395.
Takahashi K, Maita K, Kuwahara
M, Harada T, and Maronpot
RR, 1992. Eosinophilic Globule Cells in Mouse MFH-like
Sarcomas:
Lectin Histochemistry.
Virchows
Archiv B Cell Pathol. 62:89-95.
Stanley LA, Devereux TR, Foley J, Lord PG, Maronpot
RR, Orton TC, and Anderson MW, 1992. Proto-oncogene Activation in Liver Tumors
of Hepatocarcinogenesis-resistant Strains of Mice. Carcinogenesis
13:2427-2433.
Anderson MW, Reynolds
SH, You M, and Maronpot RR, 1992. Role of Proto-oncogene Activation in Carcinogenesis. EHP 98:13-24.
Cullen JM, Sandgren
EP, Brinster
RL, and Maronpot RR, 1993. Histologic
Characterization of
Hepatic Carcinogenesis in Transgenic Mice Expressing
SV40 T-antigens. Vet. Path. 30:111-118.
Melnick RL, Huff J, Barrett JC, Maronpot RR, Lucier G, and Portier CJ, 1993. Cell Proliferation
and
Chemical Carcinogenesis: A Symposium Overview.
Molecular
Carcinogenesis 7:135-138.
Anderson MW and Maronpot RR, 1993. Editorial:
Methylene Chloride-induced Tumorigenesis. Carcinogenesis 14:787-788.
Devereux TR, Foley JF, Maronpot
RR, Kari F, and Anderson
MW, 1993. Ras Proto-oncogene Activation in Liver and Lung Tumors
from B6C3F1
Mice Exposed Chronically to Methylene Chloride.
Carcinogenesis 14:795-802.
Hegi ME, Soderkvist
P, Foley JF, Schoonhoven
R, Swenberg
JA, Kari F, Maronpot R, Anderson MW, and Wiseman RW, 1993. Characterization of p53 Mutations
in Methylene Chloride-induced Lung Tumors from B6C3F1 Mice. Carcinogenesis
14:803-810.
Foley JF, Tuck PD, Ton TVT, Frost M, Kari F, Anderson
M.W, and Maronpot RR, 1993. Inhalation Exposure
to a Hepatocarcinogenic Concentration of Methylene
Chloride Does Not Induce Sustained Replicative DNA Synthesis in Hepatocytes of Female B6C3F1
Mice. Carcinogenesis 14:811-818.
Kari FW, Foley JF, Seilkop
SK, Maronpot RR, and Anderson
MW, 1993. Effect of Varying
Exposure Regimens
on Methylene Chloride-induced Lung and Liver Tumors
in Female B6C3F1
Mice. Carcinogenesis 14:819-826.
Chen B, Liu L, Castonguay
A, Maronpot RR, Anderson
MW, and You M, 1993. Dose-dependent ras
Mutation Spectra in N- nitrosodiethylamine-induced Mouse Liver Tumors and 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone Induced
Mouse Lung Tumors. Carcinogenesis 14:1603-1608.
Devereux TR, Belinsky
SA, Maronpot RR, White CM, Hegi ME, Patel AC, Foley JF, Greenwell A, and Anderson MW, 1993. Comparison
of Pulmonary 06-methylguanine DNA Adduct Levels and Ki- ras Activation
in Lung Tumors
from Resistant
and Susceptible
Mouse Strains.
Molecular Carcinogenesis 8:177-185.
Maronpot RR, Foley JF, Takahashi K, Goldsworthy T, Clark G, Tritscher A, Portier C, and Lucier G,
1993. Dose Response
for TCDD Promotion
of Hepatocarcinogenesis in Rats Initiated with DEN: Histologic,
Biochemical, and Cell Proliferation Endpoints.
EHP 101:634-642.
Johnson GA, Benveniste
H, Black RD, Hedlund
LW, Maronpot
RR, and Smith BR, 1993. Histology
by
Magnetic Resonance Microscopy. Magnetic Resonance
Quarterly 1993; 9(1):1-30.
Kanno J, Maronpot
RR, Takahashi M, Kasuga
T, and Hayashi Y, 1993. Regressive
and Non- regressive
Thyroid Lesions of the Rat Induced
by Single Injection
of N-bis(2-hydroxypropyl) nitrosamine and Iodine Deficient Diet. Carcinogenesis 14:2389-2396.
Melnick RL, Huff J, Barrett JC, Maronpot RR, Lucier G, and Portier CJ, 1993. Cell Proliferation and
Chemical Carcinogenesis:
Symposium Overview.
EHP 101:3-5.
Goldsworthy TL, Butterworth
BE, and Maronpot RR, 1993. Concepts, Labeling Procedures, and
Design of Cell Proliferation Studies Relating
to Carcinogenesis.
EHP 101:59-65.
Foley J, Ton T, Maronpot R, Butterworth B, and Goldsworthy
TL, 1993. Comparison
of Proliferating
Cell Nuclear Antigen
to Tritiated Thymidine as a Marker of Proliferating
Hepatocytes
in Rats. EHP
101:199-205.
Greenwell A, Foley JF, and Maronpot
RR, 1993. Detecting Proliferating
Cell Nuclear Antigen
in
Archival Rodent Tissues.
EHP 101:207-209.
Kanno J, Foley JF, Kari F, Anderson MW, and Maronpot RR, 1993. Effect of Methylene
Chloride
Inhalation on Replicative
DNA Synthesis
in the Lungs of Female
B6C3F1 Mice. EHP 101:271-276.
Ghanayem BI, Sanchez IM, Maronpot RR, Elwell MR, and Matthews HB, 1993. Relationship
Between the Time of Sustained
Ethyl Acrylate
Forestomach Hyperplasia
and Carcinogenicity. EHP
101:277-280.
Takahashi K, Lindamood III C, and Maronpot
RR, 1993. Retrospective Study of Possible
a-2m- globulin
Nephropathy and Associated
Cell Proliferation
in Male Fischer
344 Rats Dosed with t-butyl alcohol.
EHP 101:281-286.
Herzog CR, Schut HAJ, Maronpot
RR, and You M, 1993. Ras Mutations in 2-amino-3- methylimidazo[4,5-f]quinoline-induced Tumors
from the CDF1 Mouse. Molecular Carcinogenesis
8:202-207.
Cunningham ML, Maronpot RR, Thompson
M, and Bucher JR, 1994. Early Responses
of the Liver of B6C3F1
Mice to the Hepatocarcinogen Oxazepam:
Tox. & Appl. Pharmacol. 124:31-38
Dixon D, Yoshitomi K, Boorman GA, and Maronpot RR, 1994. “Lipomatous” Lesions of Unknown
Cellular Origin in the Liver of B6C3F1 Mice. Vet.. Path. 31:173-182.
Devereux TR, White CM, Sills RC, Bucher JR, Maronpot
RR, and Anderson MW, 1994. Low Frequency
of H-ras Mutations
in Hepatocellular Adenomas
and Carcinomas and in Hepatoblastomas from B6C3F1 Mice Exposed
to Oxazepam in the Diet. Carcinogenesis
15:1083-
1087.
Zhou X, Maronpot
RR, Mills GI, Cofer GP, Hedlund
LW and Johnson
GA, 1994: Studies
on Bromobenzene-induced Hepatotoxicity Using in vivo MR Microscopy with Surgically
Implanted RF Coils. Magnetic
Resonance in Medicine 31:619-627.
Stanley LA, Blackburn
DR, Devereaux S, Foley J, Lord PG, Maronpot
RR, Orton TC, and Anderson MW, 1994. Ras Mutations
in Methylclofenapate-induced B6C3F1 and C57BL/10J
Mouse Liver Tumours.
Carcinogenesis 15:1125-1131.
Boorman GA, Maronpot RR, and Eustis SL, 1994. Rodent Carcinogenicity Bioassay:
Past, Present, and Future. Tox. Path. 22:105-111.
Preston GA, Lang JE, Maronpot RR, and Barrett JC, 1994. Regulation of Apoptosis
by Low Serum in Cells of Different
Stages of Neoplastic Progression: Enhanced
Susceptibility
After Loss of a Senescence Gene and Decreased
Susceptibility
After Loss of a Tumor Suppressor Gene. Cancer Res. 54:4214-4223.
Anna CH, Maronpot
RR, Pereira
MA, Foley JF, Malarkey
DE, and Anderson MW, 1994. Ras Proto- oncogene
Activation in Dichloroacetic acid-, Trichloroethylene-,and Tetrachloroethylene-induced Liver Tumors
in B6C3F1
Mice. Carcinogenesis 15:2255-2261.
Davis BJ, Maronpot RR, and Heindel
JJ, 1994. Di-(2-ethylhexyl) Phthalate Suppresses
Estradiol and Ovulation
in Cycling
Rats. Tox. & Appl. Pharmacol.
128:216-223.
Goodrow TL, Nichols WW, Storer RD, Anderson
MW, and Maronpot RR, 1994. Activation of H-ras is Prevalent
in 1,3-Butadiene-induced and Spontaneously Occurring
Murine Harderian
Gland Tumors. Carcinogenesis 15:2665-2667.
Hegi ME, Devereux TR, Dietrich
WF, Cochran
CJ, Lander ES, Foley JF, Maronpot
RR, Anderson MW, and Wiseman
RW, 1994. Allelotype
Analysis of Mouse Lung Carcinomas Reveals Frequent Allelic Losses on Chromosome 4 and an Association Between
Allelic Imbalances
on Chromosome
6 and K-ras activation.
Cancer Res. 54:6257-6264.
Devereux TR, Wiseman RW, Kaplan N, Garren S, Foley JF, White CM, Anna C, Watson
MA, Patel A, Jarchow S, Maronpot
RR, and Anderson MW, 1994. Assignment of a Locus for Mouse Lung Tumor Susceptibility
to Proximal Chromosome 19. Mammalian Genome
5:749-755.
Davis LM, Caspary WJ, Sakallah
SA, Maronpot
R, Wiseman R, Barrett JC, Elliott R, and Hozier JC,
1994. Loss of Heterozygosity in Spontaneous and Chemically
induced
Tumors
of the B6C3F1
Mouse. Carcinogenesis 15:1637-1645.
Sewall CH, Flagler N, Vanden
Heuvel JP, Clark GC, Tritscher
AM, Maronpot RR, and Lucier GW,
1995. Alterations in Thyroid
Function in Female Sprague-Dawley Rats Following Chronic Treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Tox. & Appl. Pharmacol. 132:237-244.
Ton TT, Elwell MR, Morris RW, and Maronpot RR, 1995. Development and Persistence of Placental
Glutathione-S-Transferase-positive Foci in Livers of Male F344 Rats Exposed to o- Nitrotoluene.
Cancer Ltrs. 95:167-173.
Watson MA, Devereux TR, Malarkey DE, Anderson
MW, and Maronpot
RR, 1995. H-ras Oncogene Mutation Spectra in B6C3F1
and C57BL/6
Mouse Liver Tumors Provide Evidence
for TCDD Promotion of Spontaneous and Vinyl Carbamate-initiated Liver Cells. Carcinogenesis 16:1705-
1710.
Maronpot RR, Fox T, Malarkey
DE, and Goldsworthy
TL, 1995. Mutations in the ras Proto- oncogene:
Clues to Etiology and Molecular Pathogenesis
of Mouse Liver Tumors.
Toxicology
101:125-156.
Massey TE, Devereux
TR, Maronpot RR, Foley JF, and Anderson MW, 1995. High Frequency of K- ras Mutations in Spontaneous and Vinyl Carbamate-induced Lung Tumors
of Relatively Resistant B6CF1 (C57BL/6J x BALB/cJ) Mice. Carcinogenesis
16:1065-1069.
Takahashi K, Vivano CJ, Elwell MR, Bakewell
WE, Kuwahara M, Nakashima
N, Blackwell BN, and Maronpot RR, 1995. Bile Duct-specific
Lectins, Dolichos Biflorus
agglutinin
and peanut agglutinin, as Probes in Mouse Hepatocarcinogenesis. Laboratory Investigation
73:424-432.
Maronpot RR, Devereux TR, Hegi M, Foley JF, Kanno J, Wiseman R, and Anderson
MW, 1995. Hepatic
and Pulmonary Carcinogenicity
of Methylene Chloride
in Mice: A Search for Mechanisms. Toxicology 102:73-81.
Malarkey DE, Devereux
TR, Dinse GE, Mann PC, and Maronpot RR, 1995. Hepatocarcinogenicity of Chlordane in B6C3F1
and B6D2F1 Male Mice: Evidence
for Regression in B6C3F1
Mice and Carcinogenesis Independent
of ras Proto-oncogene Activation. Carcinogenesis
16:2617-2625.
Liu J, Phillips KW, Foley JF, and Maronpot RR, 1995. Optimizing in situ Hybridization
of Lactoferrin mRNA in Mouse Uterine Tissue Using Digoxigenin-labeled RNA Probes.
Cell Vision 2:430-434.
Zhou X, Maronpot RR, Hedlund
LW, Cofer GP, and Johnson
GA, 1995. Detection
of
Bromobenzene-induced Hepatocellular Necrosis Using Magnetic
Resonance Microscopy. Magnetic
Resonance in Medicine 34:853-857.
Tritscher AM, Clark GC, Sewall CS, Sills RC, Maronpot R, and Lucier GW, 1995. Persistence
of TCDD-induced
Hepatic
Cell Proliferation
and Growth
of Enzyme
Altered Foci After Chronic Exposure Followed
by Cessation of Treatment in DEN Initiated Female Rats. Carcinogenesis
16:2807-2811.
Malarkey DE and Maronpot
RR, 1996. Polymerase Chain Reaction and in situ Hybridization: Applications in Toxicological
Pathology.
Tox. Path. 24:13-23.
Goldsworthy TL, Fransson-Steen R, and Maronpot
RR, 1996. Importance of and Approaches
to
Quantification of Hepatocyte Apoptosis.
Tox. Path. 24:24-35.
Delnomdedieu M, Hedlund
LW, Johnson GA, and Maronpot RR, 1996. Magnetic
Resonance
Microscopy -- A New Tool for the Toxicologic Pathologist. Tox. Path. 24:36-44.
Portier CJ, Sherman
CD, Kohn M, Edler L, Kopp-Schneider A, Maronpot RR and Lucier G, 1996. Modeling the Number and
Size of Hepatic Focal Lesions Following
Exposure
to 2,3,7,8-TCDD. Toxicol.
Appl. Pharmacol.
138:20-30.
Maronpot RR. 1996. Editorial. Laboratory
Animal Pathology
- Emphasis
on an Area of Relevance
to the Toxicologic
Pathologist. Tox. Path. 24: 506.
Mahler JF, Stokes W,Mann
PC,Takaoka M and Maronpot RR. 1996. Spontaneous
Lesions
in Aging
FVB/N Mice. Tox. Path. 24: 710-716.
Maronpot RR. 1996.
A Symposium
Summary
and Perspective on Comparative
Molecular
Biology of Cancer. Tox. Path. 24: 801-804.
Maronpot RR and Boorman GA. 1996. The Contribution of the Mouse in Hazard Identification
Studies. Tox. Path. 24: 726-733.
Carthew P, Maronpot RR, Foley J, Edwards, RE and Dorman,BM.
1996.
A Method for Determining Whether the Number of Hepatocytes
in Rat Liver is Increased
after Treatment
with the Peroxisome Proliferator Gemfibrozil. J. Appl. Toxicol.
17: 47-51.
Donnelly, PJ, Devereux, TR, Foley, JF, Maronpot, RR, Anderson, MW and Massey,
TE. 1996. Activation of K-ras in Aflatoxin
B1-Induced Lung Tumors from AC3F1 (A/J x C3H/HeJ)
Mice. Carcinogenesis 17: 1735-1740.
Albert, RE, French, JF, Maronpot,
R, Spalding, J and Tennant,
R. 1996. Mechanisms
of Skin Tumorigenesis by contact Sensitizers:
The Effect of the corticosteroid
Fluocinolone
Acetonide on Inflammation
and Tumor Induction by 2,4 Dinitro-1-fluorobenzene in the Skin of the TG.AC (v-Ha- ras) Mouse. Environ. Hlth. Persp. 104: 1062-1068.
Kong, L-Y, McMillian,
MK, Maronpot, R, Hong, J-S. 1996. Protein tyrosine
kinase inhibitors suppress
the production of nitric oxide in mixed glia, microglia-enriched or astrocyte-enriched cultures. Brain Res. 729: 102-109.
Davis, BJ, Almekinder,
JL, Flagler,
N, Travlos, G, Wilson, R, and Maronpot, RR. 1997. Ovarian Luteal Cell Toxicity
of Ethylene
Glycol Monomethyl Ether and Methoxy
Acetic Acid in Vivo and in Vitro. Toxicol.
Appl. Pharmacol. 142: 328-337.
Fox, TR, McMillen, PJ, Maronpot,
RR and Goldsworthy,
TL. 1997. Genomic Instability,
as Measured by Microsatellite Alterations, Is Not Associated
with Liver Tumor Development in the Genetically
Susceptible
B6C3F1 Mouse. Toxocol.
Appl. Pharmacol.
143: 167-172.
Witschi, H, Espiritu,
I, Peake, JL, Wu, K, Maronpot, RR and Pinkerton,
KE. 1997. The
Carcinogenicity of Environmental Tobacco
Smoke. Carcinogenesis 18: 575-586.
Fransson-Steen, R, Goldsworthy, TL, Kedderis,
GL and Maronpot,
RR. 1997. Furan-induced liver cell proliferation and apoptosis in female B6C3F1
mice. Toxicology 118: 195-204.
Johansson, E, Reynolds,
S, Anderson,
M and Maronpot, R.
1997.
Frequency
of Ha-ras-1
Gene
Mutations Inversely Correlated
with Furan Dose in Mouse Liver Tumors. Mol. Carcinogenesis
18:
199-205.
Romach, EH, Goldsworthy,
TL, Maronpot,
RR and Fox, TR.
1997.
Altered gene expression in spontaneous hepatocellular carcinomas
from male B6C3F1
mice. Mol. Carcinogenesis
19: 31-38.
Carthew P, Maronpot RR, Foley JF, Edwards RE, and Nolan BM, 1997. Method
for determining whether the number of hepatocytes
in rat liver is increased
after treatment with the peroxisome proliferator
gemfibrozil.
J Appl Toxicol.
17: 47-51.
Maronpot RR,
1997. Comments on the medium-term
rat liver focus bioassay. Toxicol Pathol. 25:
461.
Witschi H, Espiritu
I, Peake JL, Wu K, Maronpot RR, and Pinkerton
KE, 1997. The carcinogenicity of environmental
tobacco smoke. Carcinogenesis. 18: 575-586.
Kim, T-W, Porter, KL, Foley, JF, Maronpot,
RR and Smart, RC. 1997. Evidence that mirex promotes
a unique population of epidermal cells that cannot be distinguished by their mutant Ha- ras genotype. Mol. Carcinogenesis 20: 115-124.
Mitsumori, K, Wakana, S, Yamamoto,
S, Kodama, Y, Yasuhara,
K, kNomura, T, Hayashi, Y and Maronpot, RR. 1997. Susceptibility of Transgenic Mice Carrying
Human Prototype c-Ha-ras
Gene in a Short-Term
Carcinogenicity Study of Vinyl Carbamate
and ras Gene Analyses of the Induced Tumors. Molecular
Carcinogenesis 20: 298-307.
Witschi, H, Espiritu,
I, Maronpot,
RR, Pinkerton, KE and Jones, AD.
1997.
The Carcinogenic
Potential of the Gas Phase of Environmental
Tobacco Smoke. Carcinogenesis
18: 2035-2042.
Ton, TT, Foley, JF, Flagler, ND, Gaul, BW and Maronpot, RR.
1997.
Feasibility
of Administering
5- Bromo-2’-Deoxyuridine (BRDU)
in Drinking
Water for Labeling
S-Phase Hepatocytes in Rats and Mice.
Toxicol.
Methods
7: 123-136.
Nyska A, Maronpot
RR, Eldridge SR, Haseman
JK and Hailey JR.
1997.
Alteration in Cell Kinetics in Control B6C3F1
Mice Infected with Helicobacter
hepaticus. Toxicol. Pathol. 25: 591-596.
Delnomdedieu M, Hedlund LW, Maronpot RR and Johnson GA. 1998. Magnetic Resonance Microscopy
and Histopathology:
Comparative approach of bromobenzene-Induced Hepatotoxicity in the Rat.
Hepatology 27: 526-532.
Nyska A, Leininger
JR, Maronpot
RR, Haseman JK and Hailey JR. 1998. Effect of Individual Versus Group Caging on the Incidence
of Pituitary
and Leydig Cell Tumors in F344 Rats: Proposed Mechanism. Med. Hypotheses 50: 525-529.
Enomoto A, Sandgren
EP and Maronpot,
RR. 1998. Interactive
Effects of c-myc and Transforming Growth
Factor a Transgenes
on Liver Tumor
Development in Simian
Virus 40 T Antigen
Transgenic Mice.
Vet. Pathol. 35: 283-291.
Dragan Y, Klaunig
J, Maronpot
R, and Goldsworthy T,
1998. Mechanisms
of susceptibility to mouse liver carcinogenesis.
Toxicol Sci. 41: 3-7.
Nyska A, Leininger
JR, Maronpot
RR, Haseman JK, and Hailey JR,
1998. Effect of individual versus group caging on the incidence
of pituitary
and Leydig cell tumors in F344 rats: proposed mechanism.
Med Hypotheses. 50: 525-529.
Maronpot RR.
1998.
The Potential of Genetically
Altered Mice as Animal Models for Carcinogen
Identification. Toxicol.
Pathol. 26: 579-581.
Enomoto A, Sandgren EP and Maronpot
RR. 1998. Altered
Differentiation of Hepatocytes in a
Transgenic Mouse Model of Hepatocarcinogenesis. Toxicol. Pathol. 26: 570-578.
Hailey JR, Haseman JK, Bucher JR, Radovsky
AE, Malarkey
DE, Miller RT, Nyska A and Maronpot RR.
1998.
Impact of Helicobacter
hepaticus
Infection in B6C3F1
Mice from Twelve National Toxicology Program
Two-Year Carcinogenesis
Studies. Toxicol.
Pathol. 26: 602-611.
Nyska A, Maronpot
RR, Long PH, Roycroft
JH, Hailey JR, Travlos GS and Ghanayem BI. 1999. Disseminated Thrombosis
and Bone Infarction
in Female
Rats Following
Inhalation
Exposure
to 2- Butoxyethanol. Toxicol. Pathol. 27: 21-28.
Chhabra RS, Maronpot, RR, Bucher, JR, Haseman, JK, Toft, JD and Hejtmancik,
MR.
1999. Toxicology and Carcinogenesis
Studies of Pentachlorophenol in Rats. Toxicol.
Sci. 48: 14-20
Johnson J, Murray PK and Maronpot RR.
1999.
Improved Method for Ultrastructural Preservation of Saccharomyces cerevisiae JHY-31-11D. Applied Immunohistochem and Molecular Morphology 7: 81-86.
Goldsworthy SM, Stockton
PS, Trempus CS, Foley JF and Maronpot
RR. 1999. Effects of Fixation on RNA Extraction
and
Amplification
from Laser Capture Microdissected
Tissue.
Mol.Carc. 25:86-91.
Nyska A, Haseman
JK, Hailey JR, Smetana S and Maronpot RR. 1999. The Association Between Severe Nephropathy
and Pheochromocytoma in the Male F344 Rat - The National Toxicology Program Experience. Toxicol.
Pathol. 27: 456-462.
Levin S, Bucci TJ, Cohen SM, Fix AS, Hardisty JF, LeGrand EK, Maronpot
RR and Trump BF.
1999. The Nomenclature of Cell Death: Recommendations of an ad hoc Committee
of the Society of Toxicologic
Pathologists. Toxicol.
Pathol. 27: 484-490.
Tam AS, Foley JF, Devereux TR, Maronpot
RR and Massey
TE. 1999. High Frequency and Heterogeneous
Distribution of p53 Mutations in Aflatoxin
B1-induced Mouse Lung Tumors. Cancer Res. 59: 3634-3640.
Nyska A, Maronpot
RR and Ghanayem
BI.
1999.
Ocular thrombosis and retinal degeneration induced in female F344 rats by 2-butoxyethanol. Human
& Experimental Toxicology
18: 577-582.
Witschi H, Espirtu I, Pinkerton KE, Murphy K and Maronpot RR. 1999. Ozone Carcinogenesis
Revisited. Toxicol.
Sci. 52: 162-167.
Ma J, Qu W, Scarborough
PE, Tomer KB, Moomaw CR, Maronpot, R, Davis LS, Breyer
MD and Zeldin DC. 1999. Molecular cloning,
enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome
P450 highly expressed
in kidney. J. Biol. Chem. 274: 17777-17788.
Long PH, Maronpot RR, Ghanayem
BI, Roycroft JH and Myska A. 2000. Dental Pulp Infarction
in
Female Rats Following
Inhalation
Exposure
to 2-Butoxyethanol. Toxicol.
Pathol. 28: 246-252.
Maronpot RR. 2000. The use of genetically modified animals
in carcinogenicity bioassays. Toxicol. Pathol. 28: 450-453
Maronpot RR, Mitsumori
K, Mann P, Takaoka
M, Yamamoto
S, Usui T, Okamiya H, Nishikawa S and Nomura
T. 2000. Interlaboratory comparison
of the CB6F1-Tg rasH2 rapid carcinogenicity testing model. Toxicology
146: 149-159.
Chen XJ, Hedlund LW, Moller HE, Chawla MS, Maronpot RR and Johnson GA. 2000. Detection of emphysema
in rat lungs by using magnetic resonance measurements
of 3He diffusion. PNAS 97:11478-11481.
Liomnitski L, Foley JF, Grossman S, Shaul VB, Maronpot
RR, Moomaw
CR, Carbonatto M and Nyska A. 2000. Effects of apocynin
and natural antioxidant
from spinach on inducible nitric oxide synthase and cyclooxygenase-2 induction in lipoipolysaccharide-induced hepatic injury in rat. Pharmacology
& Toxicology 87: 18-25.
Lomnitski L, Carbonatto M, Ben-Shaul
V, Peano S, Conz A, Corradin L, Maronpot
RR, Grossman S, and Nyska
A, 2000. The prophylactic effects
of natural
water-soluble
antioxidant
from spinach and apocynin in a rabbit model of lipopolysaccharide-induced endotoxemia. Toxicol Pathol. 28: 588-600.
Lomnitski L, Nyska A, Ben-Shaul V, Maronpot
RR, Haseman JK, Harrus TL, Bergman M, and Grossman S,
2000. Effects of antioxidants
apocynin
and the natural water-soluble
antioxidant from spinach
on cellular damage induced by lipopolysaccaride in the rat. Toxicol Pathol. 28: 580-587.
Maronpot RR, Mitsumori
K, Mann P, Takaoka
M, Yamamoto
S, Usui T, Okamiya H, Nishikawa S, and Nomura
T, 2000. Interlaboratory comparison
of the CB6F1-Tg
rasH2 rapid carcinogenicity testing model. Toxicology.
146: 149-159.
Sabo T, Lomnitski
L, Nyska A, Beni S, Maronpot RR, Shohami E, Roses AD, and Michaelson DM,
2000. Susceptibility of transgenic
mice expressing
human apolipoprotein
E to closed head injury: the allele E3 is neuroprotective whereas
E4 increases fatalities.
Neuroscience.
101: 879-884.
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, and Goldstein
JA,
2000. CYP2C40,
a unique arachidonic acid 16-hydroxylase, is the major CYP2C
in murine intestinal
tract. Mol Pharmacol.
58: 279-287.
Suwa, T., Nyska, A., Peckham,
JC, Hailey, JR, Mahler, JF, Haseman, JK and Maronpot, RR.
2001. A retrospective analysis
of background lesions and tissue accountabiity for male accessory
sex organs in Fischer-344
rats.
Toxicol. Pathol. 29: 467-478.
Suwa, T., Nyska, A, Haseman, JK, Mahler, JF and Maronpot, RR. 2001. Spontaneous lesions in control B6C3F1
mice and recommended section of male accessory sex organs. Toxicol. Pathol.30:228-234.
Nyska A, Lomnitski
L, Maronpot R, Moomaw C, Brodsky B, Sintov A, and Wormser
U (2001). Effects of iodine on inducible
nitric oxide synthase and cyclooxygenase- 2 expression
in sulfur mustard-induced skin. Arch Toxicol 74: 768-74.
Qu W, Bradbury
JA, Tsao CC, Maronpot
R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, and Zeldin DC (2001). Cytochrome P450 CYP2J9,
a new mouse arachidonic
acid omega-1 hydroxylase predominately
expressed in brain. J Biol Chem 276 (27): 25467-79
Johnson GA, Cofer GP, Hedlund LW, Maronpot RR and Suddarth SA. 2001. Registered 1H and
3He Magnetic
Resonance
Microscopy of the Lung.
Magnetic
Resonance
in Med. 45: 365-370.
Hayashi S, Hong HH, Toyoda K, Ton TV, Devereux
TR, Maronpot RR, Huff J, and Sills RC (2001). High frequency
of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed
to 1-amino-2,4-dibromoanthraquinone for 2 years. Toxicol Pathol 29: 422-9.
Torres-Munoz J, Stockton
P, Tacoronte
N, Roberts
B, Maronpot RR, and Petito CK (2001). Detection
of HIV-1 gene sequences in hippocampal
neurons isolated from postmortem AIDS brains by laser capture microdissection. J Neuropathol Exp Neurol 60: 885-92.
Tsao C, Coulter SJ, Chien A, Luo G, Clayton
N, Maronpot R, Goldstein
JA and Zeldin DC. 2001. Identification and localization
of five CYP2Cs
in murine extrahepatic tissues and their metabolism
of arachidonic acid to regio- and stereoselective
products. J. Pharmacol.
Exp. Therap. 299: 39-47.
Gottschling BC, Maronpot
RR, Hailey JR, Peddada
S, Moomaw
CR, Klaunig
JE and Nska A. 2001. The role of oxidative stress in indium phosphide-induced lung carcinogenesis
in rats. Toxicol Sci 64: 28-40.
Suwa T, Nyska A, Haseman
JK, Mahler JF and Maronpot RR.
2002. Spontaneous lesions in control B6C3F1
mice and recommended sectioning
of male accessory
sex organs. Toxicol Pathol 30: 228-234.
Ozaki K, Haseman JK, Hailey JR, Maronpot
RR and Nyska A. 2002. Association of adrenal pheochhromocytoma and lung pathology
in inhalation
studies with particulate compounds in the male F344 rat – The National
Toxicology Program
experience. Toxicol Pathol 30: 263-270.
Nyska A, Dayan A and Maronpot RR.
2002.
New tools in therapeutic
research
– Prostate
cancer and models. Toxicol Pathol 30: 283-287.
Okoji RS, Y RC, Maronpot RR and Froines
JR.
2002. Sodium
arsenite administration via drinking water increases genome-wide
and Ha-ras DNA hypomethylation in methyl-deficient
C57BL/6J mice.
Carcinogenesis 23: 777-785.
Johnson GA, Cofer GP, Fubara B, Gewalt SL, Hedlund LW, and Maronpot RR (2002). Magnetic resonance
histology for morphologic phenotyping. Magn Reson Imaging 16: 423-9.
Takahashi M, Dinse GE, Foley JF, Hardisty JF, and Maronpot RR (2002). Comparative prevalence,
multiplicity,
and progression
of spontaneous and vinyl carbamate-induced liver lesions in five strains of male mice. Toxicol Pathol 30: 599-605.
Ma J, Bradbury
JA, King L, Maronpot
R, Davis LS, Breyer MD and Zeldin DC. 2002.
Molecular cloning and characterization
of mouse CYP2J6, an unstable
cytochrome
P450 isoform. Biochem Pharmacol 64:1447-1460
Gallardo-Williams MT, Maronpot
RR, Wine RN, Brunssen SH and Chapin RE.
2003. Inhibition of the enzymatic
activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid. The Prostate 54:44-49.
Tam AS, Devereux
TR, Patel AC, Foley JF, Maronpot
RR and Massey
TR. 2003. Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced
mouse lung tumors. Carcinogenesis
24: 121-
132.
Ress NB, Hailey JR, Maronpot
RR, Bucher JR, Travlos GS, Haseman JK, Orzech DP, Johnson JD and Hejtmancik MR. 2003. Toxicology and carcinogenesis
studies of microencapsulated citral in rats and mice.
Toxicol Sci 71: 198-206.
Nyska A, Suttie A, Bakshi S, Lomnitski L, Grossman S, Bergman
M, Ben-Shaul
V, Crocket P, Haseman
JK, Moser G, Goldsworthy TL, and Maronpot
RR. 2003. Slowing
tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural anti-oxidant
from spinach, NAO--a comparative study of three anti-oxidants.
Toxicol Pathol 31: 39-51.
Gallardo-Williams MT, Maronpot
RR, Turner CH, Johnson
CS, Harris MW, Jayo MJ, Chapin RE. (2003) Effects of boric acid supplementation on bone histomorphometry, metabolism, and biomechanical properties
in aged female F-344 rats. Biol. Trace Element
Res. 93: 155-169.
Picut CA, Aoyama H, Holder JW, Gold LS, Maronpot RR and Dixon D. (2003). Bromoethane, chloroethane and ethylene oxide induced
uterine neoplasms
in B6C3F1 mice from 2-year inhalation
bioassyas:
pathology and incidence data revisited. Exp Toxic Pathol 55: 1-9.
Gallardo-Williams, M. T., Maronpot,
R. R., Wine, R. N., Brunssen, S. H., and Chapin, R. E. (2003). Inhibition of the enzymatic activity of prostate-specific antigen
by boric acid and 3- nitrophenyl boronic acid. Prostate 54: 44-9.
Calderon-Garciduenas, L., Maronpot,
R. R., Torres-Jardon, R., Henriquez-Roldan, C., Schoonhoven, R., Acuna-Ayala, H., Villarreal-Calderon, A., Nakamura,
J., Fernando, R., Reed, W., Azzarelli,
B., and Swenberg,
J. A. (2003). DNA damage
in nasal and brain tissues of canines exposed to air pollutants
is associated
with evidence
of chronic brain inflammation
and neurodegeneration. Toxicol Pathol 31, 524-38.
Gallardo-Williams, M. T., Maronpot,
R. R., Turner, C. H., Johnson,
C. S., Harris, M. W., Jayo, M. J., and Chapin,
R. E. (2003). Effects of boric acid supplementation on bone histomorphometry, metabolism,
and biomechanical properties
in aged female F-344 rats. Biol Trace Elem Res 93,
155-70.
Crissman, J. W., Goodman, D. G., Hildebrandt,
P. K., Maronpot, R. R., Prater, D. A., Riley, J. H., Seaman, W. J., and Thake, D. C. (2004). Best practices
guideline: toxicologic histopathology. Toxicol Pathol 32, 126-31.
Gallardo-Williams, M. T., Chapin, R. E., King, P. E., Moser,
G. J., Goldsworthy, T. L., Morrison, J. P., and Maronpot, R. R. (2004). Boron Supplementation Inhibits
the Growth and Local Expression of IGF-1 in Human
Prostate Adenocarcinoma (LNCaP)
Tumors
in Nude Mice. Toxicol Pathol 32,
73-8.
Tani, Y., Maronpot, R. R., Foley, J. F., Haseman, J. K., Walker, N. J., and Nyska, A. (2004). Follicular
Epithelial Cell Hypertrophy Induced by Chronic Oral Administration of 2,3,7,8- Tetrachlorodibenzo-p-Dioxin in Female Harlan Sprague-Dawley Rats. Toxicol Pathol 32, 41-9.
Hamadeh, H. K., Jayadev, S., Gaillard,
E. T., Huang, Q., Stoll, R., Blanchard, K., Chou, J., Tucker, C. J., Collins,
J., Maronpot, R., Bushel,
P., and Afshari,
C. A. (2004). Integration of clinical and gene expression
endpoints to explore furan-mediated
hepatotoxicity. Mutat Res 549,169-83.
Herzog, C. R., Bodon, N., Pittman, B., Maronpot,
R. R., Massey,
T. E., Anderson, M. W., You, M., and Devereux, T. R. (2004). Carcinogen-specific targeting
of chromosome
12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome
instability
and tumor progression.
Oncogene
23, 3033-9.
Maronpot, R. R., Flake, G., and Huff, J. (2004). Relevance of animal carcinogenesis findings to human cancer predictions
and prevention. Toxicol Pathol 32 Suppl 1, 40-8.
Nikitin, A. Y., Alcaraz,
A., Anver, M. R., Bronson,
R. T., Cardiff, R. D., Dixon, D., Fraire, A. E., Gabrielson, E. W., Gunning, W. T., Haines,
D. C., Kaufman, M. H., Linnoila, R. I., Maronpot, R.
R., Rabson, A. S., Reddick, R. L., Rehm, S., Rozengurt,
N., Schuller, H. M., Shmidt, E. N., Travis, W. D., Ward, J. M., and Jacks, T. (2004). Classification
of proliferative pulmonary
lesions of the mouse:
recommendations of the mouse models of human cancers
consortium.
Cancer Res 64,
2307-16.
Nyska, A., Haseman, J. K., Kohen, R., and Maronpot, R. R. (2004). Association of liver hemangiosarcoma and secondary
iron overload
in B6C3F1 mice--the
National Toxicology Program experience.
Toxicol Pathol 32, 222-8.
Allen, D. G., Pearse, G., Haseman, J. K., and Maronpot,
R. R. (2004). Prediction
of rodent carcinogenesis:
an evaluation of prechronic liver lesions as forecasters of liver tumors in NTP carcinogenicity studies. Toxicol Pathol 32, 393-401.
Sills, R., Morgan,
D., Herr, D., Little, P., George, N., Ton, T., Love, N., Maronpot,
R., and Johnson, G. (2004). Contribution of Magnetic Resonance
Microscopy in the 12-Week Neurotoxicity
Evaluation
of Carbonyl
Sulfide in Fischer
344 Rats. Toxicol Pathol 32, 501-510.
Stumpo, D. J., Byrd, N. A., Phillips, R. S., Ghosh, S., Maronpot, R. R., Castranio,
T., Meyers, E. N., Mishina, Y., and Blackshear,
P. J. (2004). Chorioallantoic fusion defects and embryonic lethality resulting
from disruption
of Zfp36L1,
a gene encoding
a CCCH tandem
zinc finger protein of the Tristetraprolin
family. Mol Cell Biol 24, 6445-55.
Calderon-Garciduenas, L., Reed, W., Maronpot,
R. R., Henriquez-Roldan, C., Delgado-Chavez, R., Calderon-Garciduenas, A., Dragustinovis, I.,
Franco-Lira,
M., Aragon-Flores,
M., Solt, A. C., Altenburg,
M., Torres-Jardon, R., and Swenberg, J. A. (2004). Brain inflammation and
Alzheimer's-like pathology
in individuals exposed
to severe air pollution. Toxicol Pathol 32, 650-8.
Maronpot, R. R., Sills, R. C., and Johnson,
G. A. (2004).
Applications
of magnetic
resonance microscopy. Toxicol Pathol 32 Suppl 2, 42-8.
Morgan, D. L., Little, P. B., Herr, D. W., Moser, V. C., Collins, B., Herbert,
R., Johnson,
G. A., Maronpot,
R. R., Harry, G. J., and Sills, R. C. (2004). Neurotoxicity
of carbonyl
sulfide in F344 rats following
inhalation
exposure
for up to 12 weeks. Toxicol Appl Pharmacol 200, 131-45.
Moyer, C., Allen, D., Basabe,
A., Maronpot,
R. R., and Nyska, A. (2004). Analysis of vascular endothelial
growth factor (VEGF) and a receptor
subtype (KDR/flk-1) in the liver of rats exposed to riddelliine:
a potential
role in the development
of hemangiosarcoma. Exp Toxicol Pathol 55,
455-65.
Yamamoto, Y., Moore, R., Goldsworthy, T. L., Negishi,
M., and Maronpot,
R. R. (2004). The orphan nuclear
receptor
constitutive active/androstane receptor
is essential for liver tumor promotion by phenobarbital in mice. Cancer Res 64, 7197-200.
Zhou, T., Jia, X., Chapin,
R. E., Maronpot, R. R., Harris, M. W., Liu, J., Waalkes,
M. P., and Eddy, E. M. (2004). Cadmium
at a non-toxic
dose alters gene expression
in mouse testes. Toxicol Lett 154, 191-200.
Malarkey, D.E., Johnson, K., Ryan, L., Boorman, G. and Maronpot, R. R. (2005). New Insights into Functional
Aspects
of Liver Morphology.
Toxicol.
Pathol..
33: 27-34.
Malarkey, D.E., Parker, J.S., Turman,
C.A., Scott, A.M., Paules, R.S., Collins,
J. and Maronpot, R. R. (2005). Microarray Data Analysis of Mouse Neoplasia. Toxicol.
Pathol. 33: 127-135.
Suttie, A. W., Dinse, G. E., Nyska, A., Moser, G. J., Goldsworthy, T. L., and Maronpot,
R. R. (2005). An investigation of the effects of late-onset
dietary restriction
on prostate cancer development
in the TRAMP mouse. Toxicol Pathol 33, 386-97.
Tani, Y., Suttie, A., Flake, G. P., Nyska, A., and Maronpot,
R. R. (2005). Epithelial-stromal tumor of the seminal
vesicles
in the transgenic
adenocarcinoma mouse prostate
model. Vet Pathol 42: 306-14.
Witschi, H., Espiritu,
I., and Maronpot,
R. R. (2006). Lung tumors in 2 year old strain A/J mice exposed for 6 months to tobacco smoke. Cancer Lett. 241: 64-68.
Tam, N. N., Nyska, A., Maronpot,
R. R., Kissling,
G., Lomnitski, L., Suttie, A., Bakshi, S., Bergman, M., Grossman, S., and Ho, S. M. (2006). Differential
attenuation
of oxidative/nitrosative injuries in early prostatic
neoplastic
lesions in TRAMP
mice by dietary antioxidants.
Prostate 66, 57-69.
Yamamoto, Y., Moore, R., Hess, H. A., Guo, G. L., Gonzalez, F. J., Korach, K. S., Maronpot,
R. R., and Negishi,
M. (2006). Estrogen
receptor
alpha mediates
17alpha -ethynylestradiol-causing hepatotoxicity. J Biol Chem 281:16625-31.
Johnson, K., Ryan, L., Davis, J., Elmore,
A., Guenther, B., Marcus,
J., and Maronpot,
R. R. (2006). Application
of magnetic
resonance imaging
in developmental neurotoxicity
testing: a pilot study. Neurotoxicology 27, 846-51.
Cardiff, R. D., Anver, M. R., Boivin, G. P., Bosenberg, M. W., Maronpot,
R. R., Molinolo, A. A., Nikitin, A. Y., Rehg, J. E., Thomas, G. V., Russell,
R. G., and Ward, J. M. (2006). Precancer
in mice: animal models used to understand, prevent, and treat human precancers. Toxicol Pathol 34, 699-707.
Maronpot, R. R. (2006). A monograph on histomorphologic evaluation of lymphoid
organs.
Toxicol Pathol 34, 407-8.
Maronpot, R. R. (2006). Enhanced
histopathology of lymphoid
tissues. Toxicol Pathol 34, 631-3.
Phillips,
J. M., Yamamoto, Y., Negishi,
M., Maronpot,
R. R. and Goodman,
J. I. (2007) Orphan nuclear receptor constitutive
active/androstane receptor-mediated alterations in DNA methylation
during phenobarbital promotion
of liver tumorigenesis. Toxicol Sci. 96: 72-82.
Guindon, K. A., Foley, J. F., Maronpot,
R. R., and Massey,
T. E. (2008). Failure of catalase
to protect against aflatoxin
B(1)-induced mouse lung tumorigenicity.
Toxicol Appl Pharmacol 227, 179-83.
Dixon, D., Herbert R. A., Kissling, G.E., Brix, A.E., Miller, R.A. and Maronpot,
R. R. (2008) Summary
of chemically
induced
pulmonary lesions in the National Toxicology
Program (NTP) Toxicology
and Carcinogenesis Studies. Toxicol Pathol 36: 428-39.
Calderon-Garciduenas, L., Mora-Tiscareno, A., Ontiveros,
E., Gomez-Garza, G., Barragan-Mejia, G., Broadway,
J., Chapman,
S., Valencia-Salazar, G., Jewells, V., Maronpot, R. R., Henriquez-Roldan, C., Perez-Guille,
B., Torres-Jardon,
R., Herrit, L., Brooks, D., Osnaya-Brizuela, N., Monroy,
M. E., Gonzalez- Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Solt, A. C., and Engle, R. W. (2008). Air pollution, cognitive deficits and brain abnormalities: A pilot study with children
and dogs. Brain Cogn. 68(2): 117-27.
Murkunde, Y.V., Vijayamumar, K.S., Hemalatha, K., Maronpot,
R.R., Herbert, R.A., Armstrong, J.M. and Wells, M.Y. (2008) Brain Lesion in a Wistar Rat. Lab Animal 37(9): 401-4.
Calderon-Garciduenas, L., Macias-Parra, M., Hoffmann,
H. J., Valencia-Salazar, G., Henriquez-Roldan, C., Osnaya,
N., Monte, O. C., Barragan-Mejia, G., Villarreal-Calderon, R., Romero,
L., Granada-Macias, M., Torres-Jardon, R., Medina-Cortina, H., and Maronpot,
R. R. (2009). Immunotoxicity
and environment: Immunodysregulation and systemic inflammation in children.
Toxicol Pathol 37, 161-169.
Moser, G. J., Foley, J., Burnett,
M., Goldsworthy,
T. L., and Maronpot, R. (2009). Furan-induced
dose- response
relationships
for liver cytotoxicity, cell proliferation, and tumorigenicity
(furan-induced liver tumorigenicity).
Exp Toxicol Pathol 61, 101-111.
Calderon-Garciduenas, L., Franco-Lira,
M., Henriquez-Roldan, C., Osnaya, N., Gonzalez-Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Herritt, L., Brooks, D., Keefe, S., Palacios-Moreno, J., Torres-Jardon,
R., Medina-Cortina, H., Delgado-Chavez, R., Aiello-Mora, M., Maronpot,
R. R., and Doty, R. L. (2009). Urban air pollution:
Influences
on
olfactory
function and pathology
in exposed children
and young adults. Exp Toxicol Pathol. Epub 2009/03/20
Moser, G. J., Foley, J., Burnett,
M., Goldsworthy,
T. L., and Maronpot, R. (2009). Furan-induced
dose- response
relationships
for liver cytotoxicity, cell proliferation, and tumorigenicity
(furan-induced liver tumorigenicity).
Exp Toxicol Pathol 61, 101-111.
Maronpot, R. R., Zeiger, E., McConnell, E. E., Kolenda-Roberts, H., Wall, H., and Friedman,
M. A. (2009). Induction of tunica vaginalis mesotheliomas in rats by xenobiotics. Crit Rev Toxicol 39, 512-537.
Calderon-Garciduenas, L., Mora-Tiscareno, A., Gomez-Garza, G., Carrasco-Portugal Mdel, C., Perez- Guille, B., Flores-Murrieta,
F. J., Perez-Guille,
G., Osnaya,
N., Juarez-Olguin, H., Monroy, M. E., Monroy, S., Gonzalez-Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Patel, S. A., Kumarathasan,
P., Vincent,
R., Henriquez-Roldan, C., Torres-Jardon, R., and Maronpot,
R. R. (2009). Effects of a cyclooxygenase-2 preferential
inhibitor
in young healthy dogs exposed
to air pollution:
A pilot study. Toxicol Pathol 37, 644-660.
Yoshizawa, K., Jelezcova,
E., Brown, A. R., Foley, J. F., Nyska, A., Cui, X., Hofseth, L. J., Maronpot,
R. M., Wilson,
S. H., Sepulveda, A. R., and Sobol, R. W. (2009). Gastrointestinal hyperplasia
with altered expression
of DNA polymerase
beta. PLoS One 4, e6493.
Arias-Loza, P. A., Muehlfelder, M., Elmore,
S. A., Maronpot, R., Hu, K., Blode, H., Hegele-Hartung, C., Fritzemeier, K. H., Ertl, G., and Pelzer, T. (2009). Differential effects of 17b -estradiol
and of synthetic progestins on aldosterone-salt induced kidney disease. Toxicol Pathol. 37(7):969-82.
Maronpot,
R. R. (2009). Biological basis of differential susceptibility to
hepatocarcinogenesis among mouse strains.
J Toxicol Pathol 22, 11-33.
Branca, R. T., Cleveland,
Z. I., Fubara, B., Kumar,
C. S., Maronpot, R. R., Leuschner,
C., Warren, W. S., and Driehuys,
B. (2010).
Molecular MRI for sensitive
and specific
detection
of lung metastases. Proc Natl Acad Sci U S A. 107(8):
3693-7.
Ghosh, S., Hoenerhoff,
M. J., Clayton, N., Myers, P., Stumpo, D. J., Maronpot,
R. R., and Blackshear, P. J. Left-sided cardiac
valvulitis
in tristetraprolin-deficient mice: The
role of
tumor
necrosis
factor alpha. (2010) Am J Pathol 176, 1484-1493.
Calderon-Garciduenas, L., Franco-Lira,
M., Henriquez-Roldan, C., Osnaya,
N., Gonzalez-Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Herritt, L., Brooks, D., Keefe, S., Palacios-Moreno, J., Torres-Jardon, R., Medina-Cortina, H., Delgado-Chavez, R., Aiello-Mora,
M., Maronpot, R. R., and Doty, R. L. ( 2010). Urban air pollution: influences on olfactory function
and pathology in exposed
children and young adults. Exp Toxicol Pathol 62, 91-102.
Rodricks, J. V., Swenberg,
J. A., Borzelleca,
J. F., Maronpot, R. R., and Shipp, A. M. Triclosan: A critical review of the experimental
data and development
of margins
of safety for consumer products. Crit Rev Toxicol 40, 422-484.
Botts, S., Ennulat,
D., Francke-Carroll, S., Graham,
M., Maronpot, R. R., and Mohutsky,
M. (2010). Introduction to hepatic drug metabolizing enzyme induction
in drug safety evaluation
studies.
Toxicol Pathol 38, 796-798.
Maronpot, R. R., Yoshizawa, K., Nyska, A., Harada,
T., Flake, G., Mueller,
G., Singh, B., and Ward, J. M. (2010). Hepatic enzyme
induction: Histopathology. Toxicol Pathol 38, 776-795.
Bach, U., Hailey, J. R., Hill, G. D., Kaufmann, W., Latimer, K. S., Malarkey,
D. E., Maronpot, R. M., Miller, R. A., Moore, R. R., Morrison,
J. P., Nolte, T., Rinke, M., Rittinghausen, S., Suttie, A. W., Travlos,
G. S., Vahle, J. L., Willson,
G. A., and Elmore, S. A. (2010). Proceedings of the 2009 National Toxicology Program
Satellite
Symposium. Toxicol Pathol 38, 9-36.
Boorman, G. A., Wolf, D. C., Francke-Carroll, S., and Maronpot, R. R. (2010). Pathology peer review.. Toxicol Pathol 38, 1009-1010.
Thoolen, B., Maronpot, R. R., Harada, T., Nyska, A., Rousseaux, C., Nolte, T., Malarkey, D. E., Kaufmann,
W., Kuttler, K., Deschl, U., Nakae, D., Gregson, R., Vinlove, M. P., Brix, A. E., Singh, B., Belpoggi, F., and Ward, J. M. (2010). Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary
system.
Toxicol Pathol 38, 5S-81S.
Villarreal-Calderon, R., Torres-Jardon,
R., Palacios-Moreno, J., Osnaya,
N., Perez-Guille,
B., Maronpot, R. R., Reed, W., Zhu, H., and Calderon-Garciduenas, L. (2010). Urban air pollution targets the dorsal vagal complex and dark chocolate offers neuroprotection. Int J Toxicol 29, 604-615.
Adams, E. T., Auerbach, S., Blackshear,
P. E., Bradley, A., Gruebbel,
M. M., Little, P. B., Malarkey, D., Maronpot, R., McKay,
J. S., Miller, R. A., Moore, R. R., Morrison,
J. P., Nyska, A., Ramot, Y., Rao, D., Suttie, A., Wells, M. Y., Willson,
G. A., and Elmore,
S. A. (2011). Proceedings of the 2010 National Toxicology Program
Satellite
Symposium. Toxicol Pathol 39, 240-266.
Maronpot, R. R. (2011). Responsible
authorship
and
publication practices.
Toxicol Pathol 39, 1029-1031. Hobbs, C. A., Swartz,
C., Maronpot,
R., Davis, J., Recio, L., and Hayashi,
S. M. (2012). Evaluation of the genotoxicity of the food additive, gum ghatti. Food Chem Toxicol 50, 854-860.
Hall, A.P., Elcombe,
C.R., Foster, J.R., Harada, T., Kaufmann, W., Knippel,
A., Kuttler, K., Malarkey, D.E., Maronpot, R.R., Nishikawa,
A., Nolte, T., Schulte, A., Strauss, V. & York, M.J. (2012). Liver Hypertrophy:A Review of Adaptive
(Adverse and Non-adverse)
Changes--Conclusions from the 3rd International ESTP Expert Workshop. Toxicol Pathol, 40, 971-994.
Carter, C.A., Misra, M. & Maronpot, R.R. (2012). Tracheal Morphologic and Protein Alterations
Following Short-Term Cigarette Mainstream Smoke Exposure to Rats. J Toxicol Pathol, 25, 201-207.
Thoolen, B., Ten Kate, F.J., van Diest, P.J., Malarkey,
D.E., Elmore, S.A. & Maronpot, R.R. (2012). Comparative
histomorphological review of rat and human hepatocellular proliferative
lesions.
J Toxicol Pathol, 25, 189-199.
Maronpot, R.R. (2012). Regulatory forum opinion piece: the role of the toxicologic pathologist in the postgenomic
era:challenges
and
opportunities. Toxicol Pathol, 40, 1082-1086.
Maronpot, R.R., Davis, J., Moser, G., Giri, D.K. & Hayashi, S.M. (2013). Evaluation
of
90-day oral rat toxicity studies on the food additive,
gum ghatti. Food Chem Toxicol.
51:215-24.
Branca,
R. T., Zhang, L., Warren, W. S., Auerbach, E., Khanna, A., Degan, S., Ugurbil,
K., and Maronpot, R. (2013). In vivo noninvasive detection of brown adipose
tissue through intermolecular zero-quantum MRI. PLoS One 8,
e74206.
Elmore,
S. A., Hoenerhoff, M., Katsuta, O., Kokoshima, H., Maronpot, R., Nagai, H.,
Satoh, H., Tanaka, Y., Tochitani, T., Tsuchiya, S., and Yoshizawa, K. (2013).
Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium. J Toxicol Pathol
26, 231-257.
Maronpot,
R. R. (2013). The role of the toxicologic pathologist in the post-genomic era. J
Toxicol Pathol 26, 105-110.
Maronpot,
R. R., Thoolen, R. J., and Hansen, B. (2015). Two-year carcinogenicity study of
acrylamide in
Wistar
Han rats with in utero exposure. Exp Toxicol Pathol 67, 189-95.
Maronpot,
R. R. (2015). Toxicological assessment of Ashitaba Chalcone. Food and Chemical
Toxicology.
77:
111-119.
Book Chapters/Fascicles
Maronpot RR, 1985. Considerations
in the Evaluation
and Interpretation
of Long-Term Animal
Bioassays for Carcinogenicity. In: Handbook of Carcinogen Testing. Noyes Pub, NJ, pp. 372-382.
Mennear J, Maronpot R, Boorman G, Eustis S, Huff J, Haseman J, McConnell
E, Ragan H, and Miller R, 1986. Toxicologic and Carcinogenic
Effects of Inhaled
Tetrachloroethylene in Rats and Mice. In: New Concepts and Developments in Toxicology. Chambers P L, Gehring
P, and Sakai F, eds. pp. 201-210.
Maronpot RR, 1986. Spontaneous
Hydronephrosis
in the Rat. In: ILSI Monograph on Pathology
of
Laboratory Animals
- Urinary System.
Springer-Verlag, NY, pp. 268-271.
Anderson MW, Maronpot
RR, and Reynolds SH, 1988. Role of Oncogenes
in Chemical Carcinogenesis: Extrapolation from Rodents
to Humans.
In: Detection Methods for DNA-Damaging Agents in Men: Applications in Cancer Epidemiology and Prevention.
Bartsch H, et al., eds. IARC Scientific Publication #89, Oxford Univ. Press, pp. 477-485.
Mitsumori K, Dittrich KL, Stefanski
S, and Maronpot RR, 1988. Benign and Malignant
Neoplasms, Meninges,
Rat. In: ILSI Monograph
on Pathology of Laboratory
Animals - Nervous
System. Springer-Verlag, NY, pp. 108-117.
Maronpot RR, 1990. Tumors of the Liver. In: Atlas of Tumor Pathology
of the Fischer Rat. CRC Press, pp. 193-220.
Belinsky SA, Walker VE, Uraih LC, Maronpot
RR, Swenberg
JA, and Anderson
MW, 1990. Role of DNA Adduct Formation
and Cell Proliferation
in the Induction
of Nasal Tumors
in the Rat by the Tobacco Specific Carcinogen 4-(N-methyl-N-nitrosamino)-1- (3-pyridyl)-1-butanone.
In: Nasal Carcinogenesis
in Rodents: Relevance to Human
Health Risk. Pudoc Wageningen, Netherlands, pp. 146-151.
You M, Reynolds
SH, Maronpot RR, Stoner GD, and Anderson MW 1990. Activated Oncogenes
in Rodent and Human
Lung Tumors.
In: Biology, Toxicology,
and Carcinogenesis of Respiratory Epithelium. Thomassen
DG and Nettesheim
P, eds. Hemisphere Publishing Co., NY, pp. 271-287.
Maronpot RR, 1991. Chemical
Carcinogenesis. In: Handbook of Toxicologic Pathology. Haschek
W
and Rosseaux CG, eds. Academic Press, NY, pp. 99-129.
Swenberg JA and Maronpot
RR, 1991. Chemically
Induced
Cell Proliferation
as a Criterion
in Selecting Doses for Long-term Bioassays.
In: Chemically
Induced
Cell Proliferation:
Implications
for Risk Assessment . Butterworth
BE, Slaga TJ, Farland
W, and McClain
M, eds. Vol. 369 of Progress in Clinical and Biological Research.
Willy-Liss, Inc., NY, pp. 245-251.
Ghanayem BI, Maronpot
RR, and Matthews
HB, 1991. Role of Chemically Induced Cell Proliferation in Ethyl Acrylate-induced Forestomach Carcinogenesis. In: Chemically Induced Cell Proliferation:
Implications
for Risk Assessment. Butterworth BE, Slaga TJ, Farland W, and McClain M, eds. Vol. 369 of Progress
in Clinical and Biological Research.
Willy-Liss, Inc., NY, pp. 337-346.
Frantz JD, Betton G, Cartwright
ME, Crissman
JW, Macklin AW, and Maronpot RR, 1991. Proliferative Lesions of the Non-glandular and Glandular Stomach in Rats. In: Guides for Toxicologic
Pathology.
STP/ARP/AFIP, Washington, DC, pp. 1-20.
Clark G, Tritscher A, Maronpot
R, Foley J, and Lucier G, 1991. Tumor Promotion by TCDD in Female
Rats. In: Banbury Report 35 - Biological
Basis for Risk Assessment
of dioxins and Related Compounds.
Cold Spring Harbor Laboratory
Press, Cold Spring Harbor,
pp. 389-404.
Anderson M, Stanley L, Devereux
T, Reynolds S, and Maronpot
R, 1992. Oncogenes
in Mouse Liver Tumors. In: Comparative Molecular Carcinogenesis. Klein-Szanto
AJP, Anderson MS, Barrett JC, and Slaga TJ, eds. Wiley-Liss,
Inc., NY, pp. 187-201.
Johnson GA, Benveniste H,
Black RR, Cofer GP, Gewalt SL, Hedlund LW, Maronpot RR, and Suddarth SA, 1992. MR Microscopy of
Disease Models. In: Magnetic Resonance
Microscopy: Methods and Applications in Materials
Science and Biomedicine.
Blumich
B and Kuhn W, eds. VHC, NY, pp. 501-511.
Dixon D and Maronpot RR, 1994. Tumours
of the Pancreas. In: Pathology of Tumours in
Laboratory Animals, Vol. 2. Tumours
of the Mouse. IARC Publications, Lyon, pp. 281-303.
Goodman DG, Maronpot RR, Newberne
PN, Popp JA, and Squire RA, 1994. Proliferative and Selected Other Lesions in the Liver of Rats. In: Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington,
DC, pp. 1-24.
Maronpot RR, Anna CH, Devereux TR, Lucier GW, Butterworth BE, and Anderson
MW, 1995. Considerations Concerning
the Murine Hepatocarcinogenicity of Selected
Chlorinated Hydrocarbons. In: Implications
for Risk Assessment. Wiley-Liss,
Inc., NY, pp. 305-323.
Davis BJ and Maronpot
RR, 1996. Chemically
Associated Toxicity
and Carcinogenicity of the Ovary. In: Cellular
and Molecular
Mechanisms
of Hormonal
Carcinogenesis. Environmental Influences. Huff J, Boyd J, and Barrett JC, eds. Wiley-Liss,
NY, pp. 285-308.
Kanno J, Ward JM, and Maronpot RR, 1996. Mechanisms of Chemically
Induced
Thyroid
Follicular Carcinogenesis. In: Cellular and Molecular Mechanisms
of Hormonal
Carcinogenesis. Environmental
Influences. Huff J, Boyd J, and Barrett JC, eds. Wiley-Liss,
NY, pp. 353-398.
Devereux TR, Malarkey
DE and Maronpot,
RR. 1996. The contribution
of rodent liver and lung carcinogenesis models to our knowledge of the cancer latent period. In Maltoni, C. (ed) , The Scientific Bases of Cancer Chemoprevention. Elsevier
Publications,
Amsterdam,
Netherlands.
pp.
45-59.
Harada, T, Maronpot,
RR, Enomoto, A, Tamano,
S and Ward, JM.
1996.
Changes in the liver and gallbladder. In: Pathobiology
of the Aging Mouse. Volume
2. Mohr, U, Dungworth,
DL, Capen, CC, Carlton,
WW, Sundberg, JP and Ward, JM (Eds).
ILSI Press, Washington,
DC. pp: 207-241.
Maronpot, RR. 1998. Chemical
Carcinogenesis. In: Fundamentals
of Toxicologic
Pathology. Haschek,
WM and Rousseaux, CG (Eds). Academic
Press, New York. pp. 15-35
Maronpot, RR. 1998. Carcinogenesis. In: Encyclopedia
of Toxicology. Wexler, P. (Ed.). Academic
Press, Ney York.
pp. 246-268.
Nyska A and Maronpot RR. 1999. Adrenal
gland. In: Pathology of the Mouse. Maronpot
RR, Boorman
GA and Gaul BW (Eds.). Cache River Press, Vienna,
IL.
pp. 509-536.
Harada T, Enomoto
A, Boorman
GA and Maronpot RR. 1999. Liver and gallbladder. . In: Pathology of the Mouse. Maronpot RR, Boorman GA and Gaul BW (Eds.). Cache River Press, Vienna, IL.
pp. 119-184.
Mastroides S and Maronpot RR (2002) Carcinogenesis. In: Handbook
of Toxicologic Pathology. 2nd
Edition.Haschek WM, Russeaue
CG and Wallig MA (Eds). Academic
Press, San Diego. pp. 83-
122.
Malarkey DE and Maronpot RR (2005) Carcinogenesis. In: Encyclopedia
of Toxicology. 2nd Edition.
Wexler, P (Ed). Elsevier, New York.
pp. 445-466.
Maronpot, R. R. (2007) Cancer Bioassays. In: The Cancer Handbook, Second
Edition. Alison, MR (Ed). John Wiley and Sons Ltd., West Sussex,
England.
Co-Edited Symposia Proceedings
Alison R and Maronpot RR, 1987. Comparative Ovarian
Pathology.
EHP 73:3-130.
Maronpot RR and Stitzel KA, 1989. Significance
of Foci of Cellular
Alteration in the Rat Liver. Tox. Path. 17, No. 4 (Part 1), 557-735.
Uraih LC, Morgan KT, and Maronpot
RR, 1990. Symposium
on Toxicologic
Pathology of the Upper
Respiratory System. EHP
85:161-352.
Edited Books
Maronpot RR, Boorman
GA and Gaul BW. 1999. Pathology
of the Mouse. Cache River Press, Vienna, Va.
699 pages.
Pathology of Genetically Engineered
Mice. 2000. Ward, JM, Mahler,
JF, Maronpot, RR,Sundberg, JP (Eds).
Iowa State University Press, Ames, Iowa.
pp. 394.
Edited Monographs
Guest Editor for A Monograph
on Histomorphologic
Evaluation
of Lymphoid Organs
(2006). Toxicol Pathol 34 (5): 407-696.
Production of Educational CDs
Lesions of Genetically
Altered Mice. Version 2. June 2001.
A Digitized Atlas of Mouse Liver Lesions. Version 1. April 2002.
A Digitized Atlas of Mouse Liver Lesions. Version 2. June 2002.
An Exercise in Peer Review: The Pathology Working Group. An STP Satellite
Symposium. June 14, 2003.
A Digitized Atlas of Rat Liver Lesions. Version 1. June 2004.
A Digitized Atlas of Mouse Liver Lesions. Version 3. June 2004.